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PF-1355

Catalog No. T3511 CAS 1435467-38-1

Synonyms: PF-06281355, PF 06281355, ZINC205721785

PF-1355 (PF 06281355) is a selective 2-thiouracil mechanism-based MPO inhibitor. PF-1355 is used for treatment of vasculitic diseases.

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PF-1355, CAS 1435467-38-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 372.00
100 mg	In stock	$ 537.00
200 mg	In stock	$ 768.00
500 mg	In stock	$ 1,150.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 99.77%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PF-1355 (PF 06281355) is a selective 2-thiouracil mechanism-based MPO inhibitor. PF-1355 is used for treatment of vasculitic diseases.
In vitro	PF-1355 inhibits MPO activity in phorbol ester-stimulated human neutrophils as measured by taurine chlorination (EC50=1.47 μM) as well as lipopolysaccharide-treated human blood measuring residual MPO activity (EC50=2.03 μM) [1].
In vivo	Administering PF-1355 orally diminishes MPO activity in plasma, lessens vascular edema and neutrophil recruitment, and increases circulating cytokines levels. PF-1355 treatment entirely inhibits albuminuria and chronic renal dysfunction in a model of anti-glomerular basement membrane disease [1].

Synonyms	PF-06281355, PF 06281355, ZINC205721785
Molecular Weight	321.35
Formula	C14H15N3O4S
CAS No.	1435467-38-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (124.5 mM), Sonication is recommended.

References and Literature

1. Zheng W, et al. PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis. J Pharmacol Exp Ther. 2015 May;353(2):288-98

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PF-1355 1435467-38-1 Metabolism Glutathione Peroxidase PF 1355 PF-06281355 PF 06281355 ZINC 205721785 PF1355 PF06281355 ZINC205721785 ZINC-205721785 inhibitor inhibit

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