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AZD8309

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Purity:99.67%

ee:100%

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COA FNMR LCMS HNMR HPLC CSFC

AZD8309

Catalog No. T25131Cas No. 333742-48-6

AZD8309 is a potent, orally available antagonist of the chemokine receptor CXCR2 that regulates neutrophil transport, significantly reduces MPO in the pancreas and lung, and decreases trypsin and elastase activity in the pancreas.AZD8309 can be used to study a range of inflammatory diseases.

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Pack Size	Price	Availability
1 mg	$129	In Stock
5 mg	$322	In Stock
10 mg	$463	In Stock
25 mg	$712	In Stock
50 mg	$953	In Stock
100 mg	$1,280	In Stock
500 mg	$2,570	In Stock

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Product Introduction

Bioactivity

Description	AZD8309 is a potent, orally available antagonist of the chemokine receptor CXCR2 that regulates neutrophil transport, significantly reduces MPO in the pancreas and lung, and decreases trypsin and elastase activity in the pancreas.AZD8309 can be used to study a range of inflammatory diseases.
In vivo	Oral dministration of AZD8309 (50 mg/kg) reduced neutrophil migration and pancreatic protease activation in experimental pancreatitis in mice.[1]
Alias	AZD 8309, AZD-8309

Chemical Properties

Molecular Weight	384.42
Formula	C15H14F2N4O2S2
Cas No.	333742-48-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/mL (169.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6013 mL	13.0066 mL	26.0132 mL	130.0661 mL
5 mM	0.5203 mL	2.6013 mL	5.2026 mL	26.0132 mL
10 mM	0.2601 mL	1.3007 mL	2.6013 mL	13.0066 mL
20 mM	0.1301 mL	0.6503 mL	1.3007 mL	6.5033 mL
50 mM	0.0520 mL	0.2601 mL	0.5203 mL	2.6013 mL
100 mM	0.0260 mL	0.1301 mL	0.2601 mL	1.3007 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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