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Product Introduction

Bioactivity

Description	Artemotil (SM-227) is a new, fast-acting antimalarial drug.
Targets&IC50	P. falciparum:1.61 nM (IC50)
Alias	β-Arteether, SM-227, Beta-Arteether, Arteether, (+)-Arteether

Chemical Properties

Molecular Weight	312.4
Formula	C₁₇H₂₈O₅
Cas No.	75887-54-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 16.67 mg/mL (53.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2010 mL	16.0051 mL	32.0102 mL	160.0512 mL
5 mM	0.6402 mL	3.2010 mL	6.4020 mL	32.0102 mL
10 mM	0.3201 mL	1.6005 mL	3.2010 mL	16.0051 mL
20 mM	0.1601 mL	0.8003 mL	1.6005 mL	8.0026 mL
50 mM	0.0640 mL	0.3201 mL	0.6402 mL	3.2010 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ParasiteInhibitorArtemotilb-ArteetherSM227SM 227inhibit