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S07-2010
🥰Excellent
Catalog No. T61485Cas No. 1223194-71-5
Alias S072010
S07-2010 is an AKR1C3 inhibitor with potential anti-cancer activity, suppressing AKR1C3, AKR1C4, AKR1C1, and AKR1C2, inducing apoptosis in A549/DDP cells. S07-2010 exhibits significant cytotoxicity in MCF-7/DOX and A549/DDP.
S07-2010
🥰Excellent
Catalog No. T61485Alias S072010Cas No. 1223194-71-5
S07-2010 is an AKR1C3 inhibitor with potential anti-cancer activity, suppressing AKR1C3, AKR1C4, AKR1C1, and AKR1C2, inducing apoptosis in A549/DDP cells. S07-2010 exhibits significant cytotoxicity in MCF-7/DOX and A549/DDP.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $52 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | S07-2010 is an AKR1C3 inhibitor with potential anti-cancer activity, suppressing AKR1C3, AKR1C4, AKR1C1, and AKR1C2, inducing apoptosis in A549/DDP cells. S07-2010 exhibits significant cytotoxicity in MCF-7/DOX and A549/DDP. |
| Targets&IC50 | AKR1C4:0.36 μM, AKR1C1:0.47 μM, AKR1C3:0.19 μM, AKR1C2:0.73 μM |
| In vitro | S07-2010 (0-25 μM, 48h) was shown to be cytotoxic to MCF-7/DOX and A549/DDP with IC50 = 127.5 and 5.51 μM. In A549/DDP cells, S07-2010 can significantly reverse cancer cell resistance to DDP and inhibit tumor proliferation at low concentrations. In A549/DDP cells, the CI values of S07-2010 ranged from 0.2 to 0.6, indicating a strong synergistic drug effect in the combination therapy. S07-2010 (25 μM) can induce apoptosis of tumor cells. [1] |
| Alias | S072010 |
| Molecular Weight | 371.45 |
| Formula | C19H21N3O3S |
| Cas No. | 1223194-71-5 |
| Smiles | O=C1N=C(SCC(=O)C2=CC=C3NC(=O)CCCC3=C2)NC(=C1)CCC |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (80.76 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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