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S07-2010
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Catalog No. T61485Cas No. 1223194-71-5
S07-2010 is a potent pan-AKR1C inhibitor, effectively inhibiting AKR1C3, AKR1C4, AKR1C1, and AKR1C2 with IC50 values of 0.19, 0.36, 0.47, and 0.73 μM, respectively. This compound induces apoptosis in A549/DDP cells, enhances the cytotoxicity of chemotherapeutic agents in drug-resistant cells, and significantly inhibits the proliferation of drug-resistant cells [1].
S07-2010
😃Good
Catalog No. T61485Cas No. 1223194-71-5
S07-2010 is a potent pan-AKR1C inhibitor, effectively inhibiting AKR1C3, AKR1C4, AKR1C1, and AKR1C2 with IC50 values of 0.19, 0.36, 0.47, and 0.73 μM, respectively. This compound induces apoptosis in A549/DDP cells, enhances the cytotoxicity of chemotherapeutic agents in drug-resistant cells, and significantly inhibits the proliferation of drug-resistant cells [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $52 | 5 days |
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Chemical Properties
| Description | S07-2010 is a potent pan-AKR1C inhibitor, effectively inhibiting AKR1C3, AKR1C4, AKR1C1, and AKR1C2 with IC50 values of 0.19, 0.36, 0.47, and 0.73 μM, respectively. This compound induces apoptosis in A549/DDP cells, enhances the cytotoxicity of chemotherapeutic agents in drug-resistant cells, and significantly inhibits the proliferation of drug-resistant cells [1]. |
| In vitro | S07-2010, at concentrations ranging from 0-25 μM over 48 hours, demonstrates significant cytotoxic effects on MCF-7/DOX and A549/DDP cells, with respective IC50 values of 127.5 μM and 5.51 μM [1]. |
| Molecular Weight | 371.45 |
| Formula | C19H21N3O3S |
| Cas No. | 1223194-71-5 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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