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Dicoumarol

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Purity:99.9%

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COA HPLC HNMR

Dicoumarol

Catalog No. T0809Cas No. 66-76-2

Dicoumarol (Dicumarol) is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicoumarol is a competitive inhibitor of vitamin K epoxidereductase; thus, it inhibits vitamin K recycling and causes depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes, and inhibits blood clotting.

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Pack Size	Price	Availability	Quantity
500 mg	$41	In Stock

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Product Introduction

Bioactivity

Description	Dicoumarol (Dicumarol) is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicoumarol is a competitive inhibitor of vitamin K epoxidereductase; thus, it inhibits vitamin K recycling and causes depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes, and inhibits blood clotting.
Targets&IC50	PDK1:19.42 μM, NQO1:0.37 μM
Alias	Dicumarol

Chemical Properties

Molecular Weight	336.3
Formula	C19H12O6
Cas No.	66-76-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 6.73 mg/mL (20 mM)

Ethanol: 62 mg/mL (184.4 mM)

H2O: Insoluble

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.9735 mL	14.8677 mL	29.7354 mL	148.6768 mL
5 mM	0.5947 mL	2.9735 mL	5.9471 mL	29.7354 mL
10 mM	0.2974 mL	1.4868 mL	2.9735 mL	14.8677 mL
20 mM	0.1487 mL	0.7434 mL	1.4868 mL	7.4338 mL

Ethanol

	1mg	5mg	10mg	50mg
50 mM	0.0595 mL	0.2974 mL	0.5947 mL	2.9735 mL
100 mM	0.0297 mL	0.1487 mL	0.2974 mL	1.4868 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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