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CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells including multiple myeloma and can degrade mutated and overexpressed CDK6.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $728 | Backorder | |
10 mg | $996 | Backorder | |
50 mg | $2,190 | Backorder | |
100 mg | Inquiry | Backorder | |
200 mg | Inquiry | Backorder | |
1 mL x 10 mM (in DMSO) | $1,057 | Backorder |
Description | CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells including multiple myeloma and can degrade mutated and overexpressed CDK6. |
Targets&IC50 | CDK6:2.1 nM (Dc50), Cereblon: |
In vitro | In human glioblastoma U251 cells, CP-10 induces nearly 72% degradation of CDK6 at 10 nM and 89% at 100 nM. The degradation of CDK4 induced by CP-10 is far weaker than that of CDK6 (DC50: 50-80 fold). CP-10 displays a cell inhibition potential in mantle cell lymphoma cells (in Mino, IC50≈8 nM) and multiple myeloma cell MM.1S (IC50≈10 nM). |
Molecular Weight | 871.94 |
Formula | C44H49N13O7 |
Cas No. | 2366268-80-4 |
Relative Density. | 1.55 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 200 mg/mL (229.37 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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