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5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone
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Catalog No. TN3084Cas No. 1353676-65-9
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone demonstrated a strong anti-proliferative effect on ER-positive breast cancer MCF-7 cells in vitro, with an IC50 value of 4.41 μM. It significantly down-regulated the expression of estrogen receptor-α (ER-α) and inhibited tumor growth in the BCAP-37 human breast cancer cell line xenograft model.
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone
😃Good
Catalog No. TN3084Cas No. 1353676-65-9
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone demonstrated a strong anti-proliferative effect on ER-positive breast cancer MCF-7 cells in vitro, with an IC50 value of 4.41 μM. It significantly down-regulated the expression of estrogen receptor-α (ER-α) and inhibited tumor growth in the BCAP-37 human breast cancer cell line xenograft model.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $1,920 | Backorder | |
| 1 mL x 10 mM (in DMSO) | $2,280 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone demonstrated a strong anti-proliferative effect on ER-positive breast cancer MCF-7 cells in vitro, with an IC50 value of 4.41 μM. It significantly down-regulated the expression of estrogen receptor-α (ER-α) and inhibited tumor growth in the BCAP-37 human breast cancer cell line xenograft model. |
| In vitro | We found that 5,7,3′,4′-tetrahydroxy-3-methoxy-8,5′-diprenylflavone showed potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro (with an IC50 of 4.41 μM).[1] |
| In vivo | We found that 5,7,3′,4′-tetrahydroxy-3-methoxy-8,5′-diprenylflavone strongly down-regulated expression concentrations of estrogen receptor-α (ER-α) and were able to inhibit tumor growth in a xenograft model of the human breast cancer line BCAP-37 in vivo.[1] |
| Molecular Weight | 452.5 |
| Formula | C26H28O7 |
| Cas No. | 1353676-65-9 |
| Smiles | O=C1C(OC)=C(OC=2C1=C(O)C=C(O)C2CC=C(C)C)C=3C=C(O)C(O)=C(C3)CC=C(C)C |
| Relative Density. | 1.35 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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