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5MPN

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5MPN

Catalog No. T40565Cas No. 47208-82-2

5MPN is an orally active and selective inhibitor of 6-phosphofructokinase-2-kinase (PFKFB4) that competitively inhibits the F6P binding site and inhibits the proliferation of myeloma cells, and can be used in the study of myeloproliferative neoplasms.

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Product Introduction

Bioactivity

Description	5MPN is an orally active and selective inhibitor of 6-phosphofructokinase-2-kinase (PFKFB4) that competitively inhibits the F6P binding site and inhibits the proliferation of myeloma cells, and can be used in the study of myeloproliferative neoplasms.
In vitro	In H460 cells, 5MPN (0-30 μM; 24 hours) is able to inhibit the expression of PFKFB4[2].
In vivo	In C57BL/6 mice, 5MPN (120 mg/kg; oral administration) was able to suppress the growth of Lewis lung adenocarcinoma (LLC) growing in syngeneic mice and human H460 lung adenocarcinoma xenografts growing in athymic mice, without affecting the mice's body weight[1].
Alias	5-MPN

Chemical Properties

Molecular Weight	305.33
Formula	C15H19N3O4
Cas No.	47208-82-2

Storage & Solubility Information

Storage

store at low temperature|Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (262.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2751 mL	16.3757 mL	32.7514 mL	163.7572 mL
5 mM	0.6550 mL	3.2751 mL	6.5503 mL	32.7514 mL
10 mM	0.3275 mL	1.6376 mL	3.2751 mL	16.3757 mL
20 mM	0.1638 mL	0.8188 mL	1.6376 mL	8.1879 mL
50 mM	0.0655 mL	0.3275 mL	0.6550 mL	3.2751 mL
100 mM	0.0328 mL	0.1638 mL	0.3275 mL	1.6376 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc