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NMS-0963

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Catalog No. T87026Cas No. 2765304-82-1

NMS-0963 (compound 1), an orally active inhibitor of spleen tyrosine kinase (SYK), demonstrates an IC50 value of 3 nM. Additionally, NMS-0963 effectively inhibits the proliferation of the BaF3-TEL/SYK cell line at 27 nM [1].

NMS-0963

NMS-0963

😃Good
Catalog No. T87026Cas No. 2765304-82-1
NMS-0963 (compound 1), an orally active inhibitor of spleen tyrosine kinase (SYK), demonstrates an IC50 value of 3 nM. Additionally, NMS-0963 effectively inhibits the proliferation of the BaF3-TEL/SYK cell line at 27 nM [1].
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10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
NMS-0963 (compound 1), an orally active inhibitor of spleen tyrosine kinase (SYK), demonstrates an IC50 value of 3 nM. Additionally, NMS-0963 effectively inhibits the proliferation of the BaF3-TEL/SYK cell line at 27 nM [1].
Chemical Properties
Molecular Weight451.52
FormulaC23H29N7O3
Cas No.2765304-82-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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