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2-Deoxy-D-glucose
Catalog No. T6742Cas No. 154-17-6
Alias NSC 15193, D-Arabino-2-deoxyhexose, Ba 2758, 2-DG, 2-deoxyglucose, 2-Deoxy-D-arabino-hexose
2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity.
2-Deoxy-D-glucose
Catalog No. T6742Alias NSC 15193, D-Arabino-2-deoxyhexose, Ba 2758, 2-DG, 2-deoxyglucose, 2-Deoxy-D-arabino-hexoseCas No. 154-17-6
2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 mg | $33 | In Stock | |
| 1 g | $45 | In Stock | |
| 5 g | $113 | In Stock | |
| 10 g | $163 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock |
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Purity:99.77%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity. |
| In vitro | METHODS: Pancreatic cancer cells MIA PaCa2, BxPC-3, ASPC-1 and ovarian cancer cells OVCAR-3, HEY, SK-OV-3 were treated with 2-Deoxy-D-glucose (0.01-100 mM) for 48 h. Cell proliferation was detected using MTT. RESULTS: 2-Deoxy-D-glucose showed significant antiproliferative activity against tumor cells with IC50 values ranging from 1.45-13.34 mM. [1] METHODS: Triple-negative breast cancer cells Hs578T were treated with 2-Deoxy-D-glucose (15 mM) for 24 days, and cell motility was detected by Migration assay and Invasion assay. RESULTS: 2-Deoxy-D-glucose inhibited the migration and invasion of Hs578T cells. [2] |
| In vivo | METHODS: To study the effects on leukocyte subpopulation distribution and function, 2-Deoxy-D-glucose (500-1500 mg/kg) was injected intraperitoneally into BDF1 mice once or thrice. RESULTS: Blood glucose concentrations increased in a dose-dependent manner in mice injected with up to 1500 mg/kg of 2-Deoxy-D-glucose. Corticosterone levels, leukocyte counts in the spleen, and CD3+ cells in the thymus increased after one or three injections of 2-Deoxy-D-glucose up to 1500 mg/kg. 2-Deoxy-D-glucose administration induced dose-dependent changes in thymic and splenic cell distribution and function. [3] METHODS: To test the antitumor activity in vivo, 2-Deoxy-D-glucose (1000 mg/kg) was administered intraperitoneally to C57BL/6 mice bearing melanoma B16 once daily for eight days. RESULTS: 2-Deoxy-D-glucose significantly inhibited tumor growth, and TAMs showed a significant decrease in Arg, Fizz, CD206 and Vegf expression after 2-Deoxy-D-glucose treatment. [4] |
| Cell Research | 2×103 H460 or H157 cells are seeded in 96-well cell culture plates. Cells are treated with 5 mM 2-DG only, 5 or 10 μM IGF1R inhibitor II only, or a combination of 2-DG and IGF1R inhibitor II. Cell growth inhibition is determined after 48 h by the CellTiter 96® AQueous nonradioactive cell proliferation assay. (Only for Reference) |
| Alias | NSC 15193, D-Arabino-2-deoxyhexose, Ba 2758, 2-DG, 2-deoxyglucose, 2-Deoxy-D-arabino-hexose |
| Molecular Weight | 164.16 |
| Formula | C6H12O5 |
| Cas No. | 154-17-6 |
Storage & Solubility Information
| Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 100 mg/mL (609.16 mM)  DMSO: 60 mg/mL (365.5 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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