This is the immunodominant epitope gB-8p from herpes simplex virus (HSV) glycoprotein B (gB), amino acids 498 to 505.

Retrocyclin-2 is an antimicrobial peptide effective against human immunodeficiency virus (HIV), influenza A, and herpes simplex virus (HSV) [1].

XQ2B is a cGAS inhibitor that impedes protein-DNA interactions and phase separation. It suppresses antiviral immune responses induced by herpes simplex virus 1 (HSV-1) and augments HSV-1 infection in both in vitro and in vivo settings [1].

Retrocyclin-3 is an antimicrobial peptide that exhibits activity against human immunodeficiency virus (HIV), influenza A, and herpes simplex virus (HSV) [1].

FSL-1 TFA, a toll-like receptor 2/6 (TLR2/6) agonist derived from bacteria, bolsters resistance against experimental HSV-2 infection[1] and stimulates MMP-9 production via the TLR2 and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells[2].

Golotimod (SCV 07) is an antimicrobial dipeptide with immunomodulatory activity that significantly improves the efficacy of anti-tuberculosis therapy, induces thymic and splenic cell proliferation, modulates macrophage function, and inhibits STAT3 signaling.Golotimod has been used in the study of recurrent genital Herpes Simplex Virus 2 (HSV-2) infection and oral mucositis.

Bovine Myeloid Antimicrobial Peptide (BMAP) 28, a synthetic peptide derived from bovine cathelicidin-5 (amino acids 132-158), exhibits antimicrobial activity against E. coli, S. aureus, MRSA, S. epidermidis, and the fungus C. albicans, with minimum inhibitory concentrations (MICs) of 2, 2, 4, 1, and 8 µM respectively. At a concentration of 200 nM, BMAP 28 permeabilizes the inner membrane of E. coli, and at 5 µM, it inhibits herpes simplex virus 1 (HSV-1) replication in Vero 76 cells. Furthermore, at 30 µM, it causes hemolysis in human erythrocytes and cytotoxicity in human neutrophils. In vivo, a dose of 0.8 mg/kg enhances survival in mice infected with E. coli or MRSA, but not P. aeruginosa.

GLR-19 is an anti-HIV peptide with demonstrated antiviral activity against HSV-2 [1] [2].

Astodrimer (SPL7013 free base), a large (3-4 nm, ~16.5 kDa) and negatively charged dendrimer, possesses potent virucidal capabilities. Exhibiting antiviral and virucidal activities, it effectively targets a wide array of viruses, including SARS-CoV-2, HIV-1, HSV-1, HSV-2, and HPV. Additionally, Astodrimer demonstrates antibacterial properties [1] [2] [3].

FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578) is a fluorescein isothiocyanate (FITC)-labeled segment of the HHV-2 Envelope Glycoprotein G encompassing amino acids 561 to 578. This region is an immunodominant part of glycoprotein G (gG-2) and exhibits reactivity with all herpes simplex virus type 2 (HSV-2) sera [1].

HBA(111-142), a C-terminal 32-mer fragment of alpha-hemoglobin, exhibits antibacterial activity against the ESKAPE panel of pathogens, forms amyloid fibrils, and possesses antiviral activities, notably inhibiting the measles virus and herpes viruses (HSV-1, HSV-2, HCMV) [1].

HHV-2 Envelope Glycoprotein G (552-574), an immunodominant region within glycoprotein G (gG-2), demonstrates reactivity with all herpes simplex (HSV-2) sera [1].

Histone H4 (2-21) is a pivotal core histone involved in the process of chromatinization specific to the genomes of herpes simplex virus 1 (HSV-1).