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Cytarabine hydrochloride

Catalog No. T1272LCas No. 69-74-9
Alias Cytosine Arabinoside hydrochloride, Ara-C hydrochloride

Cytarabine hydrochloride (Ara-C hydrochloride) is a nucleoside analog that causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC 50 of 16 nM. Cytarabine hydrochloride has antiviral effects against HSV.

Cytarabine hydrochloride

Cytarabine hydrochloride

Purity: 99.62%
Catalog No. T1272LAlias Cytosine Arabinoside hydrochloride, Ara-C hydrochlorideCas No. 69-74-9
Cytarabine hydrochloride (Ara-C hydrochloride) is a nucleoside analog that causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC 50 of 16 nM. Cytarabine hydrochloride has antiviral effects against HSV.
Pack SizePriceAvailabilityQuantity
50 mg$33In Stock
100 mg$47In Stock
200 mg$68In Stock
500 mg$112In Stock
1 mL x 10 mM (in DMSO)$52In Stock
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Purity:99.62%
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Product Introduction

Bioactivity
Description
Cytarabine hydrochloride (Ara-C hydrochloride) is a nucleoside analog that causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC 50 of 16 nM. Cytarabine hydrochloride has antiviral effects against HSV.
In vitro
Cytarabine is converted into its active form, Ara-CTP (tri-phosphate), by the enzyme deoxycytidine kinase (dCK). It then competes with the natural nucleotide dCTP for incorporation into DNA, ultimately inhibiting DNA synthesis by disrupting DNA and RNA polymerases' functions. This compound exhibits potent growth inhibitory effects on wild-type CCRF-CEM cells, with an IC50 of 16 nM, showcasing higher efficacy compared to other acute myelogenous leukemia (AML) cells. Moreover, Cytarabine is capable of inducing apoptosis in rat sympathetic neurons at a concentration of 10 μM, with the highest observed toxicity at 100 μM, resulting in over 80% cell death within 84 hours. This process involves the release of mitochondrial cytochrome-c and activation of caspase-3, with noted attenuation of toxicity via p53 knockdown and a delay through bax deletion.
In vivo
Cytarabine (250 mg/kg) induces placental growth retardation and elevates apoptosis of trophoblastic cells in the placental labyrinth zone in pregnant Slc:Wistar rats. This effect begins 3 hours post-treatment, peaks at 6 hours, and reverts to baseline at 48 hours. It notably increases p53 protein levels and the expression of p53 transcriptional target genes, such as p21, cyclinG1, fas, and activates caspase-3 [3]. Additionally, Cytarabine effectively combats acute leukemias by causing a characteristic G1/S phase block and cell synchronization, thereby extending the survival of leukemic Brown Norway rats. Its effectiveness shows a weak dose-related pattern, suggesting that higher doses do not enhance its anti-leukemic effect in humans [4].
AliasCytosine Arabinoside hydrochloride, Ara-C hydrochloride
Chemical Properties
Molecular Weight279.68
FormulaC9H14ClN3O5
Cas No.69-74-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (178.78 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.5755 mL17.8776 mL35.7551 mL178.7757 mL
5 mM0.7151 mL3.5755 mL7.1510 mL35.7551 mL
10 mM0.3576 mL1.7878 mL3.5755 mL17.8776 mL
20 mM0.1788 mL0.8939 mL1.7878 mL8.9388 mL
50 mM0.0715 mL0.3576 mL0.7151 mL3.5755 mL
100 mM0.0358 mL0.1788 mL0.3576 mL1.7878 mL

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