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Ilaprazole sodium hydrate
🥰Excellent
Catalog No. T78218Cas No. 2322264-11-7
Alias IY-81149 sodium hydrate
Ilaprazole (IY-81149) sodium hydrate is an orally active proton pump inhibitor that irreversibly inhibits H+/K+-ATPase in rabbit parietal cells with a dose-dependent IC50 of 6 μM. It is used in gastric ulcer research and acts as a potent inhibitor of T-lymphokine-activated killer cell-originated protein kinase (TOPK) [1] [2].
Ilaprazole sodium hydrate
🥰Excellent
Purity: 99.2%
Catalog No. T78218Alias IY-81149 sodium hydrateCas No. 2322264-11-7
Ilaprazole (IY-81149) sodium hydrate is an orally active proton pump inhibitor that irreversibly inhibits H+/K+-ATPase in rabbit parietal cells with a dose-dependent IC50 of 6 μM. It is used in gastric ulcer research and acts as a potent inhibitor of T-lymphokine-activated killer cell-originated protein kinase (TOPK) [1] [2].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $49 | In Stock |
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Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, weak base that crosses the parietal cell membrane and enters the acidic parietal cell canaliculus where it becomes protonated, producing the active metabolite sulfenamide, which forms an irreversible covalent bond with two sites of the H+/K+-ATPase enzyme located on the gastric parietal cell, thereby inhibiting both basal and stimulated gastric acid production.
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Purity:99.2%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ilaprazole (IY-81149) sodium hydrate is an orally active proton pump inhibitor that irreversibly inhibits H+/K+-ATPase in rabbit parietal cells with a dose-dependent IC50 of 6 μM. It is used in gastric ulcer research and acts as a potent inhibitor of T-lymphokine-activated killer cell-originated protein kinase (TOPK) [1] [2]. |
| In vitro | In rabbit parietal cell preparations, Ilaprazole sodium hydrate irreversibly inhibits H+/K(+)-ATPase in a dose-dependent manner, with an IC50 for pump inhibitory activity of 6.0 × 10(-6) mol/L at pH 7.4[1]. |
| In vivo | In male SD rats (after pylorus ligation), Ilaprazole sodium hydrate (3, 10, 30 mg/kg; intraduodenally) significantly inhibits gastric acid secretion and volume[1]. |
| Alias | IY-81149 sodium hydrate |
| Molecular Weight | 424.45 |
| Formula | C19H21N4NaO4S |
| Cas No. | 2322264-11-7 |
| Smiles | O=S(CC1=NC=CC(OC)=C1C)C2=NC3=C([N-]2)C=C(N4C=CC=C4)C=C3.[Na+].O.O |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (9.42 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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