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Fiacitabine
🥰Excellent
Catalog No. T15280Cas No. 69123-90-6
Alias NSC 382097, FOAC, FIAC
Fiacitabine (NSC-382097) is a selective inhibitor of DNA replication of the herpes simplex virus(HSV) (IC50: 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively).
Fiacitabine
🥰Excellent
Purity: 99.21%
Catalog No. T15280Alias NSC 382097, FOAC, FIACCas No. 69123-90-6
Fiacitabine (NSC-382097) is a selective inhibitor of DNA replication of the herpes simplex virus(HSV) (IC50: 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $163 | In Stock | |
| 5 mg | $347 | In Stock | |
| 10 mg | $497 | In Stock | |
| 25 mg | $796 | In Stock | |
| 50 mg | $1,080 | In Stock | |
| 100 mg | $1,450 | In Stock | |
| 500 mg | $2,920 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $382 | In Stock |
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Purity:99.21%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Fiacitabine (NSC-382097) is a selective inhibitor of DNA replication of the herpes simplex virus(HSV) (IC50: 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively). |
| Targets&IC50 | HSV1:2.5 nM, HSV2:12.6 nM |
| In vitro | FIAC was active at much lower concentrations than arabinosylcytosine, iododeoxyuridine, and arabinosyladenine. It was slightly more active against herpes simplex virus type 1 than acycloguanosine and slightly more toxic to normal cells. FIAC was about 8,000 times more active against the replication of wild-type herpes simplex virus type 1 than against a mutant strain lacking the expression of a virus-specified thymidine kinase. HSV FIAC suppressed by 90% the replication of various strains of herpes simplex virus types 1 and 2 at concentrations of 0.0025 to 0.0126 microM. Cytotoxicity was minimal, as determined by trypan blue dye exclusion with norman Vero, WI-38, and NC-37 cell proliferation; the 50% inhibitory dose was 4 to 10 microM in a 4-day assay [2]. |
| Alias | NSC 382097, FOAC, FIAC |
| Molecular Weight | 371.1 |
| Formula | C9H11FIN3O4 |
| Cas No. | 69123-90-6 |
| Smiles | Nc1nc(=O)n(cc1I)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F |
| Relative Density. | 2.44 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 35 mg/mL (94.31 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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