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Antiviralagent 58 (Compound J1) is an orally active antiviral agent that exhibits broad-spectrum activity against enveloped viruses. It effectively targets various pathogens, including Influenza A virus (IAV), Respiratory Syncytial Virus (RSV), Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Human Coronavirus OC43 (HCoV-OC43), and Herpes Simplex Virus types 1 and 2 (HSV-1 and HSV-2).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | Inquiry | 10-14 weeks | |
50 mg | Inquiry | 10-14 weeks |
Description | Antiviralagent 58 (Compound J1) is an orally active antiviral agent that exhibits broad-spectrum activity against enveloped viruses. It effectively targets various pathogens, including Influenza A virus (IAV), Respiratory Syncytial Virus (RSV), Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Human Coronavirus OC43 (HCoV-OC43), and Herpes Simplex Virus types 1 and 2 (HSV-1 and HSV-2). |
In vitro | Antiviral Agent 58 (Compound J1) (6.25-200 μM; 48 h) demonstrates low cytotoxicity in A549, MDCK, Vero-E6, and HRT18 cells at a concentration of 200μM. Furthermore, it effectively inhibits infection by various IAV strains such as H1N1, H7N9, H5N1, and H3N2, including oseltamivir-resistant strains, with IC50 values ranging between 7.81-15.65 μM. |
In vivo | Antiviral agent 58 (Compound J1) (15-60 mg/kg; oral; once daily for 5 consecutive days) significantly mitigates influenza virus-induced pulmonary damage in BALB/c mice. |
Molecular Weight | 399.87 |
Formula | C24H18ClN3O |
Cas No. | 939655-35-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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