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LDC4297 hydrochloride
🥰Excellent
Catalog No. T72385Cas No. 2319747-14-1
LDC4297 hydrochloride is a selective and efficient CDK7 inhibitor with broad-spectrum antiviral activity. It inhibits herpesvirus, adenovirus, poxvirus, retrovirus, and positive-strand RNA viruses. It can be used for research on viral infections.
LDC4297 hydrochloride
🥰Excellent
Catalog No. T72385Cas No. 2319747-14-1
LDC4297 hydrochloride is a selective and efficient CDK7 inhibitor with broad-spectrum antiviral activity. It inhibits herpesvirus, adenovirus, poxvirus, retrovirus, and positive-strand RNA viruses. It can be used for research on viral infections.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $46 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | LDC4297 hydrochloride is a selective and efficient CDK7 inhibitor with broad-spectrum antiviral activity. It inhibits herpesvirus, adenovirus, poxvirus, retrovirus, and positive-strand RNA viruses. It can be used for research on viral infections. |
| Targets&IC50 | HHV-6A:0.04 μM (EC50), EBV:1.21 μM (EC50), MCMV:0.07 μM (EC50), Influenza A:0.99 μM (EC50), HIV-1 (NL4-3):1.04 μM (EC50), poxvirus:0.77 μM (EC50), HIV-1 (4LIG7):1.13 μM (EC50), HAdV-2:0.25 μM (EC50), HCMV:0.02 μM (EC50), HSV2:0.27 μM (EC50), Fibroblasts (human):4.5 μM (GI50), HCMV:24.5 nM (EC50), HSV1:0.02 μM (EC50), GPCMV:0.05 μM (EC50, CDK7:0.13 nM, VZV:0.06 μM (EC50) |
| In vitro | LDC4297 hydrochloride is a highly selective CDK7 inhibitor with an IC50 value of 0.13 nM. LDC4297 hydrochloride (0-10 μM, 6 days treatment) dose-dependently inhibited HCMV replication with an EC50 value of 24.5 nM. LDC4297 hydrochloride (20 μM, 12-96 hours treatment) exhibited anti-HCMV activity by multiple mechanisms including blocking virus-induced Rb phosphorylation. LDC4297 hydrochloride (20 μM, 12-96 hrs) demonstrated anti-HCMV activity through multiple mechanisms, including blocking virus-induced Rb phosphorylation. [1] LDC4297 hydrochloride (0-10 μM, treated for 4 days) exhibited anti-proliferative effects on primary cultures of human-derived fibroblasts (HFF) with a GI50 value of 4.5 μM. [1] LDC4297 hydrochloride (concentration range 0-10 μM, treatment for 7 days) exhibited a broad spectrum of antiviral effects against a wide range of viruses, including HCMV, GPCMV, MCMV, HHV-6A, HSV-1, HSV-2, VZV, EBV, HAdV-2, poxvirus, HIV-1 (nl4-3), HIV-1 ( 4LIG7) and influenza A virus, with corresponding EC50 values of 0.02 μM, 0.05 μM, 0.07 μM, 0.04 μM, 0.02 μM, 0.27 μM, 0.06 μM, 1.21 μM, 0.25 μM, 0.77 μM, 1.04 μM, 1.13 μM, and 0.99 μM, respectively. [1] |
| In vivo | LDC4297 hydrochloride (100 mg/kg, single oral dose) showed promising pharmacokinetic properties. [1] |
| Molecular Weight | 468.98 |
| Formula | C23H29ClN8O |
| Cas No. | 2319747-14-1 |
| Smiles | Cl.N1=CC=CN1C=2C=CC=CC2CNC3=NC(=NC4=C(C=NN34)C(C)C)OC5CNCCC5 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (170.58 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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