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Brivudine

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Purity:99.4%

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COA HPLC HNMR

Brivudine

Catalog No. T0718Cas No. 69304-47-8

Brivudine (BVDU), an antiviral medicine, is used in the therapy of herpes zoster.

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Pack Size	Price	Availability
25 mg	$39	In Stock
50 mg	$55	In Stock
100 mg	$72	In Stock
200 mg	$98	In Stock
500 mg	$158	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Product Introduction

Bioactivity

Description	Brivudine (BVDU), an antiviral medicine, is used in the therapy of herpes zoster.
In vitro	Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases thereby inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus than reference compounds such as aciclovir or penciclovir[1]. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage[2].
In vivo	At a dose of 125 mg once daily, brivudine has been shown to be superior to aciclovir with respect to reducing the period of new blister production and shortening the duration of post-herpetic neuralgia[1].
Alias	Bromovinyldeoxyuridine, BVDU

Chemical Properties

Molecular Weight	333.14
Formula	C11H13BrN2O5
Cas No.	69304-47-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (150.09 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0017 mL	15.0087 mL	30.0174 mL	150.0871 mL
5 mM	0.6003 mL	3.0017 mL	6.0035 mL	30.0174 mL
10 mM	0.3002 mL	1.5009 mL	3.0017 mL	15.0087 mL
20 mM	0.1501 mL	0.7504 mL	1.5009 mL	7.5044 mL
50 mM	0.0600 mL	0.3002 mL	0.6003 mL	3.0017 mL
100 mM	0.0300 mL	0.1501 mL	0.3002 mL	1.5009 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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