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Pritelivir

🥰Excellent
Catalog No. T2504Cas No. 348086-71-5
Alias BAY 57-1293, AIC316

Pritelivir (BAY 57-1293) (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM).

Pritelivir

Pritelivir

🥰Excellent
Purity: 99.42%
Catalog No. T2504Alias BAY 57-1293, AIC316Cas No. 348086-71-5
Pritelivir (BAY 57-1293) (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM).
Pack SizePriceAvailabilityQuantity
5 mg$39In Stock
10 mg$55In Stock
25 mg$88In Stock
50 mg$122In Stock
100 mg$197In Stock
500 mg$489In Stock
1 mL x 10 mM (in DMSO)$43In Stock
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Purity:99.42%
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Product Introduction

Bioactivity
Description
Pritelivir (BAY 57-1293) (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM).
Targets&IC50
HSV1/HSV2:20 nM, HSV2:20 nM
In vitro
In models of lethal disseminated herpes infection in mice and rats, as well as in a mouse model simulating the spread of shingles-like skin disease, BAY57-1293 (administered orally at doses of 0.5/15 mg/kg) exhibited potent antiviral activity. This compound also showed similar efficacy in a mouse model of ocular herpes.
In vivo
BAY57-1293 exhibits a dose-dependent direct inhibition of the viral helicase-primase complex's ATPase activity. It also demonstrates significant antiviral activity against acyclovir-resistant herpes simplex virus mutants. Additionally, in green monkey kidney cells, BAY57-1293 reduces the levels of Aβ and P-tau induced by herpes simplex virus type 1.
Kinase Assay
In vitro procaspase-3 activation: Procaspase-3 is expressed and purified in Escherichia coli. Various concentrations of PAC-1 are added to 90 μL of a 50 ng/mL of procaspase-3 in caspase assay buffer in a 96-well plate, The plate is incubated for 12 hours at 37 °C. A 10 μL volume of a 2 mM solution of caspase-3 peptidic substrate acetyl Asp-Glu-Val-Asp-p-nitroanilide (Ac-DEVD-pNa) in caspase assay buffer is then added to each well. The plate is read every 2 minutes at 405 nm for 2 hours in a Spectra Max Plus 384 well plate reader. The slope of the linear portion for each well is determined, and the relative increase in activation from untreated control wells is calculated.
AliasBAY 57-1293, AIC316
Chemical Properties
Molecular Weight402.49
FormulaC18H18N4O3S2
Cas No.348086-71-5
SmilesO=C(N(C)C1=NC(C)=C(S(N)(=O)=O)S1)CC2=CC=C(C3=CC=CC=N3)C=C2
Relative Density.1.396 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 21.67 mg/mL (53.83 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4845 mL12.4227 mL24.8453 mL124.2267 mL
5 mM0.4969 mL2.4845 mL4.9691 mL24.8453 mL
10 mM0.2485 mL1.2423 mL2.4845 mL12.4227 mL
20 mM0.1242 mL0.6211 mL1.2423 mL6.2113 mL
50 mM0.0497 mL0.2485 mL0.4969 mL2.4845 mL

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