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E6-272
🥰Excellent
Catalog No. T89394Cas No. 945142-65-4
Alias E6272, E 6-272
E6-272, an inhibitor of HPV 16 (human papillomavirus 16), induced early and late apoptosis in HPV16-positive cervical cancer cells and inhibited the proliferation of HPV16-infected cells SiHa and CaSki with GI50 values of 32.56 and 62.09 nM, respectively.
E6-272
🥰Excellent
Catalog No. T89394Alias E6272, E 6-272Cas No. 945142-65-4
E6-272, an inhibitor of HPV 16 (human papillomavirus 16), induced early and late apoptosis in HPV16-positive cervical cancer cells and inhibited the proliferation of HPV16-infected cells SiHa and CaSki with GI50 values of 32.56 and 62.09 nM, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $42 | In Stock | |
| 5 mg | $93 | In Stock | |
| 10 mg | $148 | In Stock | |
| 25 mg | $298 | In Stock | |
| 50 mg | $448 | In Stock | |
| 100 mg | $672 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $97 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | E6-272, an inhibitor of HPV 16 (human papillomavirus 16), induced early and late apoptosis in HPV16-positive cervical cancer cells and inhibited the proliferation of HPV16-infected cells SiHa and CaSki with GI50 values of 32.56 and 62.09 nM, respectively. |
| In vitro | Methods: SIHA and CASKI cells were treated with E6-272 (15nM; 30nM, 48 hours) and apoptosis analysis was performed to evaluate the efficacy of E6-272 in inducing apoptosis in cervical cancer cells. Results: E6-272 (15nM) treatment of SIHA cells induced 27.85% early and 8.38% late apoptotic cell populations (Figure 8). E6-272 (30nM) treatment of CASKI cells showed 23.94% and 7.42% early and late apoptotic cell populations, respectively.[1] |
| Alias | E6272, E 6-272 |
| Molecular Weight | 384.51 |
| Formula | C26H28N2O |
| Cas No. | 945142-65-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 8 mg/mL (20.81 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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