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E6-272

🥰Excellent
Catalog No. T89394Cas No. 945142-65-4
Alias E6272, E 6-272

E6-272, an inhibitor of HPV 16 (human papillomavirus 16), induced early and late apoptosis in HPV16-positive cervical cancer cells and inhibited the proliferation of HPV16-infected cells SiHa and CaSki with GI50 values of 32.56 and 62.09 nM, respectively.

E6-272

E6-272

🥰Excellent
Catalog No. T89394Alias E6272, E 6-272Cas No. 945142-65-4
E6-272, an inhibitor of HPV 16 (human papillomavirus 16), induced early and late apoptosis in HPV16-positive cervical cancer cells and inhibited the proliferation of HPV16-infected cells SiHa and CaSki with GI50 values of 32.56 and 62.09 nM, respectively.
Pack SizePriceAvailabilityQuantity
1 mg$42 In Stock
5 mg$93 In Stock
10 mg$148 In Stock
25 mg$298 In Stock
50 mg$448 In Stock
100 mg$672 In Stock
1 mL x 10 mM (in DMSO)$97 In Stock
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Product Introduction

Bioactivity
Description
E6-272, an inhibitor of HPV 16 (human papillomavirus 16), induced early and late apoptosis in HPV16-positive cervical cancer cells and inhibited the proliferation of HPV16-infected cells SiHa and CaSki with GI50 values of 32.56 and 62.09 nM, respectively.
In vitro
Methods: SIHA and CASKI cells were treated with E6-272 (15nM; 30nM, 48 hours) and apoptosis analysis was performed to evaluate the efficacy of E6-272 in inducing apoptosis in cervical cancer cells.
Results: E6-272 (15nM) treatment of SIHA cells induced 27.85% early and 8.38% late apoptotic cell populations (Figure 8). E6-272 (30nM) treatment of CASKI cells showed 23.94% and 7.42% early and late apoptotic cell populations, respectively.[1]
AliasE6272, E 6-272
Chemical Properties
Molecular Weight384.51
FormulaC26H28N2O
Cas No.945142-65-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 8 mg/mL (20.81 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6007 mL13.0036 mL26.0071 mL130.0356 mL
5 mM0.5201 mL2.6007 mL5.2014 mL26.0071 mL
10 mM0.2601 mL1.3004 mL2.6007 mL13.0036 mL
20 mM0.1300 mL0.6502 mL1.3004 mL6.5018 mL

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