Shopping Cart
- Remove All
Your shopping cart is currently empty
MDL-800
Catalog No. T64529Cas No. 2275619-53-7
Alias MDL800, MDL 800
MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.
MDL-800
Catalog No. T64529Alias MDL800, MDL 800Cas No. 2275619-53-7
MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $51 | In Stock | |
| 5 mg | $120 | In Stock | |
| 10 mg | $178 | In Stock | |
| 25 mg | $301 | In Stock | |
| 50 mg | $451 | In Stock | |
| 100 mg | $663 | In Stock | |
| 500 mg | $1,390 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "MDL-800"
Nicotinamide
Cited
Vitamin PP, Vitamin B3, Nicotinic acid amide, Niacinamide
T093498-92-0
Niacinamide is an important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutr
- $32
Size
QTY
CitedResveratrol
Cited
trans-Resveratrol, SRT 501
T1558501-36-0
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.
- $36
Size
QTY
CitedFisetin Cited
T2879528-48-3
Fisetin belongs to a group of natural flavonols with a variety of biological activities, including anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects.
- $41
Size
QTY
CitedDihydrocoumarin
melilotin, Hydrocoumarin, Chroman-2-one, 3,4-dihydrocoumarin, 2-chromanone
T2S0300119-84-6
Dihydrocoumarin (melilotin) is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.
- $29
Size
QTY
Nicotinamide riboside Cited
T137951341-23-7
Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities.
- $50
Size
QTY
CitedSRT 2104
SRT2104, sirtuin modulator, GSK2245840
T66791093403-33-8
SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.
- $38
Size
QTY
Sirtinol Cited
T6671410536-97-9
Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).
- $36
Size
QTY
CitedJGB1741
ILS-JGB-1741
T220941256375-38-8In house
JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. It modulates the Bax/Bcl2 ratio, cytochrome c release, and PARP cleavage, and increases acetylated p53 levels, leading to p53-mediated apoptosis. JGB1741 can be used in breast cancer studies.
- $54
Size
QTY
3-TYP Cited
3-(1H-1,2,3-triazol-4-yl) pyridine
T4108120241-79-4
3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.
- $52
Size
QTY
CitedMC3482
T119622922280-86-0In house
MC3482 is a specific inhibitor of sirtuin5 (SIRT5).
- $48
Size
QTY
SIRT6-IN-5
SIRT6 inhibitor-5, SIRT6 inhibitor5, SIRT6 inhibitor 5, SIRT6 IN 5
T24793891002-11-2In house
SIRT6-IN-5（SIRT6 inhibitor 5） is a potent and selective SIRT6 inhibitor with an IC50 value of 34 μM.SIRT6-IN-5 is immunosuppressive and chemo-sensitizing, increases H3K9 acetylation and glucose uptake in cultured cells, and reduces T-cell proliferation.
- $51
Size
QTY
Salvianolic acid B
lithospermic acid B, Dan Shen Suan B
T5725121521-90-2
Salvianolic acid B is a water-soluble antioxidant from Salvia extract. Salvianolic acid B plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant, and antithrombotic effect.
- $60
Size
QTY
Select Batch
Purity:100%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer. |
| In vitro | MDL-800 increased SIRT6 deacetylase activity with an EC50 value of 11.0 ± 0.3 μM; MDL-800 (10-50 μM) induced dose-dependent deacetylation of histone H3 in 12 NSCLC cell lines. Treatment with MDL-800 dose dependently inhibited the proliferation of 12 NSCLC cell lines with IC50 values ranging from 21.5 to 34.5 μM. The antiproliferation effect of MDL-800 was significantly diminished by SIRT6 knockout. Treatment with MDL-800 induced remarkable cell cycle arrest at the G0/G1 phase in NSCLC HCC827 and PC9 cells. Furthermore, MDL-800 (25, 50 μM) enhanced the antiproliferation of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in osimertinib-resistant HCC827 and PC9 cells as well as in patient-derived primary tumor cells, and suppressed mitogen-activated protein kinase (MAPK) pathway.[1] |
| In vivo | In HCC827 cell-derived xenograft nude mice, intraperitoneal administration of MDL-800 (80 mg · kg-1 · d-1, for 14 days) markedly suppressed the tumor growth, accompanied by enhanced SIRT6-dependent histone H3 deacetylation and decreased p-MEK and p-ERK in tumor tissues.[1] |
| Alias | MDL800, MDL 800 |
| Molecular Weight | 626.3 |
| Formula | C21H16BrCl2FN2O6S2 |
| Cas No. | 2275619-53-7 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (71.85 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy MDL-800 | purchase MDL-800 | MDL-800 cost | order MDL-800 | MDL-800 chemical structure | MDL-800 in vivo | MDL-800 in vitro | MDL-800 formula | MDL-800 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.