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Forodesine hydrochloride

Catalog No. T11313Cas No. 284490-13-7

Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP.

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Pack Size	Price	Availability	Quantity
5 mg	$1,670	7-10 days

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Product Introduction

Bioactivity

Description	Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP.
In vitro	Forodesine (BCX-1777), in the presence of 2'-deoxyguanosine (dGuo, 3-10 μM), inhibits human lymphocyte proliferation activated by various agents such as interleukin-2 (IL-2), mixed lymphocyte reaction (MLR) and phytohemagglutinin (PHA) (IC50 values
In vivo	In the hu-PBL-SCID mouse model, Forodesine (BCX-1777) demonstrates efficacy in extending lifespan by two-fold or greater. This compound exhibits outstanding oral bioavailability (63%) in mice. When administered at a single dose of 10 mg/kg, it significantly increases dGuo levels to around 5 μM.
Alias	BCX-1777 hydrochloride, Immucillin-H hydrochloride

Chemical Properties

Molecular Weight	302.71
Formula	C11H15ClN4O4
Cas No.	284490-13-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 16.67 mg/mL (55.07 mM)

H2O: 16.67 mg/mL (55.07 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0330 mL	0.1652 mL	0.3303 mL	1.6517 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Forodesine hydrochlorideForodesine HydrochlorideBCX 1777 HydrochlorideImmucillin-H HydrochlorideBCX-1777 HydrochlorideBCX1777 Hydrochloride