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Forodesine hydrochloride

Catalog No. T11313Cas No. 284490-13-7
Alias Immucillin-H hydrochloride, BCX-1777 hydrochloride

Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP.

Forodesine hydrochloride
Other Forms of Forodesine hydrochloride:
ForodesineT15337209799-67-7
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Forodesine hydrochloride

Catalog No. T11313Alias Immucillin-H hydrochloride, BCX-1777 hydrochlorideCas No. 284490-13-7
Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP.
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5 mg$1,6707-10 days
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Product Introduction

Bioactivity
Description
Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP.
Targets&IC50
PNP (human):1.19 nM , PNP (monkey):0.66 nM , PNP (mouse):0.48 nM , PNP (rat):1.24 nM , PNP (dog):1.57 nM
In vitro
Forodesine (BCX-1777), in the presence of 2'-deoxyguanosine (dGuo, 3-10 μM), inhibits human lymphocyte proliferation activated by various agents such as interleukin-2 (IL-2), mixed lymphocyte reaction (MLR) and phytohemagglutinin (PHA) (IC50 values
In vivo
In the hu-PBL-SCID mouse model, Forodesine (BCX-1777) demonstrates efficacy in extending lifespan by two-fold or greater. This compound exhibits outstanding oral bioavailability (63%) in mice. When administered at a single dose of 10 mg/kg, it significantly increases dGuo levels to around 5 μM.
AliasImmucillin-H hydrochloride, BCX-1777 hydrochloride
Chemical Properties
Molecular Weight302.71
FormulaC11H15ClN4O4
Cas No.284490-13-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 16.67 mg/mL (55.07 mM), Sonication is recommended.
H2O: 16.67 mg/mL (55.07 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM3.3035 mL16.5175 mL33.0349 mL165.1746 mL
5 mM0.6607 mL3.3035 mL6.6070 mL33.0349 mL
10 mM0.3303 mL1.6517 mL3.3035 mL16.5175 mL
20 mM0.1652 mL0.8259 mL1.6517 mL8.2587 mL
50 mM0.0661 mL0.3303 mL0.6607 mL3.3035 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

Forodesine hydrochlorideForodesine HydrochlorideBCX 1777 HydrochlorideImmucillin-H HydrochlorideBCX-1777 HydrochlorideBCX1777 Hydrochloride
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