Shopping Cart

Remove All

Your shopping cart is currently empty

Forodesine

Select Batch

Resource Download

COA HNMR HPLC LCMS

Forodesine

Catalog No. T15337Cas No. 209799-67-7

Forodesine (BCX-1777) is an orally active and potent purine nucleoside phosphorylase (PNP) inhibitor, a new purine nucleoside analog, inhibitor of human lymphocyte proliferation, induces apoptosis in leukemic cells by increasing dGTP levels, and may be useful in the study of cutaneous T-cell lymphomas.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability	Quantity
2 mg	$59	5 days

Bulk & Custom

Add to Cart

Questions

Product Introduction

Bioactivity

Description	Forodesine (BCX-1777) is an orally active and potent purine nucleoside phosphorylase (PNP) inhibitor, a new purine nucleoside analog, inhibitor of human lymphocyte proliferation, induces apoptosis in leukemic cells by increasing dGTP levels, and may be useful in the study of cutaneous T-cell lymphomas.
In vitro	Formodicin (10-30 μM; 24 and 48 hours; RPMI-8226, MOLT-4 and 5T33MM cells) has no effect on MM cells at 24 hours, but decreases the percentage of viable cells in MOLT-4 cells by 40% [1]. Treatment with forodosine (10-30 μM; 24 and 48 h; RPMI-8226, MOLT-4 and 5T33MM cells) partially inhibited cell proliferation [1]. In the presence of 2'-deoxyguanosine (dGuo, 3-10 μM), fordifloxacin inhibits the proliferation of human lymphocytes activated by a variety of drugs such as interleukin-2 (IL-2), mixed lymphocyte reaction (MLR) and phytohemagglutinin (PHA) (IC50 values less than 0.1-0.38 μM) [2].
In vivo	Forodesine has excellent oral bioavailability (63%) in mice[2]. Forodesine(single dose of 10 mg/kg; in mice ) treatment, elevates dGuo to approximately 5 μM[2]. Forodesine is effective in prolonging the life span 2-fold or more, in the human peripheral blood lymphocyte severe combined immunodeficiency (hu-PBL-SCID) mouse model[2].
Alias	Immucillin-H, BCX-1777

Chemical Properties

Molecular Weight	266.25
Formula	C11H14N4O4
Cas No.	209799-67-7

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (300.47 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7559 mL	18.7793 mL	37.5587 mL	187.7934 mL
5 mM	0.7512 mL	3.7559 mL	7.5117 mL	37.5587 mL
10 mM	0.3756 mL	1.8779 mL	3.7559 mL	18.7793 mL
20 mM	0.1878 mL	0.9390 mL	1.8779 mL	9.3897 mL
50 mM	0.0751 mL	0.3756 mL	0.7512 mL	3.7559 mL
100 mM	0.0376 mL	0.1878 mL	0.3756 mL	1.8779 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc