Shopping Cart
- Remove All
Your shopping cart is currently empty
GABAA receptor agent 4
😃Good
Catalog No. T60481Cas No. 2035203-91-7
GABAA receptor agent 4 (compound 1e) is a potent antagonist of γ-GABAAR, exhibiting a Ki of 0.18 µM, and demonstrates immunomodulatory potential by effectively rescuing the inhibition of T cell proliferation [1].
GABAA receptor agent 4
😃Good
Catalog No. T60481Cas No. 2035203-91-7
GABAA receptor agent 4 (compound 1e) is a potent antagonist of γ-GABAAR, exhibiting a Ki of 0.18 µM, and demonstrates immunomodulatory potential by effectively rescuing the inhibition of T cell proliferation [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
Bulk & Custom
Add to Cart
Questions
View MoreContact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | GABAA receptor agent 4 (compound 1e) is a potent antagonist of γ-GABAAR, exhibiting a Ki of 0.18 µM, and demonstrates immunomodulatory potential by effectively rescuing the inhibition of T cell proliferation [1]. |
| In vitro | Compound 1e, a GABAA receptor antagonist, exhibits varying inhibitory concentrations (IC50s) across subtypes: 4.95 μM (α1β2δ), 0.195 μM (α4β1δ), 0.250 μM (α4β2δ), 1.95 μM (α6β2δ), 2.18 μM (α1β2γ2), 7.56 μM (α2β2γ2), 0.56 μM (α3β2γ2), and 0.54 μM (α5β2γ2) [1]. Additionally, at a concentration of 50 μM over 96 hours, Compound 1e counteracts alprazolam-induced proliferation inhibition in both human PBMC and mouse splenocyte populations, demonstrating minimal cellular toxicity [1]. |
| Molecular Weight | 272.39 |
| Formula | C17H24N2O |
| Cas No. | 2035203-91-7 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy GABAA receptor agent 4 | purchase GABAA receptor agent 4 | GABAA receptor agent 4 cost | order GABAA receptor agent 4 | GABAA receptor agent 4 chemical structure | GABAA receptor agent 4 in vitro | GABAA receptor agent 4 formula | GABAA receptor agent 4 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.