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PLX-3618
PLX-3618 is a monovalent direct degrader capable of degrading BRD4 with a DC50 of 12.2 nM. It promotes the polyubiquitination and subsequent proteasomal degradation of BRD4 by recruiting the E3 ubiquitin ligase substrate receptor DCAF11. Furthermore, PLX-3618 inhibits the proliferation of various cancer cells and induces apoptosis in AML cells. It also demonstrates anti-tumor activity against AML in mouse models.
Catalog No. T88470Cas No. 2851986-76-8
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PLX-3618
Catalog No. T88470Cas No. 2851986-76-8
PLX-3618 is a monovalent direct degrader capable of degrading BRD4 with a DC50 of 12.2 nM. It promotes the polyubiquitination and subsequent proteasomal degradation of BRD4 by recruiting the E3 ubiquitin ligase substrate receptor DCAF11. Furthermore, PLX-3618 inhibits the proliferation of various cancer cells and induces apoptosis in AML cells. It also demonstrates anti-tumor activity against AML in mouse models.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Bioactivity
Chemical Properties
| Description | PLX-3618 is a monovalent direct degrader capable of degrading BRD4 with a DC50 of 12.2 nM. It promotes the polyubiquitination and subsequent proteasomal degradation of BRD4 by recruiting the E3 ubiquitin ligase substrate receptor DCAF11. Furthermore, PLX-3618 inhibits the proliferation of various cancer cells and induces apoptosis in AML cells. It also demonstrates anti-tumor activity against AML in mouse models. |
| Molecular Weight | 601.68 |
| Formula | C32H27N9O2S |
| Cas No. | 2851986-76-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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