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CBR-5884

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Purity:100%

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COA HNMR LCMS

CBR-5884

Catalog No. T14884Cas No. 681159-27-3

CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH

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Pack Size	Price	Availability
2 mg	$39	In Stock
5 mg	$63	In Stock
10 mg	$97	In Stock
25 mg	$228	In Stock
50 mg	$395	In Stock
100 mg	$589	In Stock
1 mL x 10 mM (in DMSO)	$68	In Stock

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Product Introduction

Bioactivity

Description

In vitro

CBR-5884 (15 or 30 μM; 3-5 days) selectively inhibits breast cancer lines that have a high propensity for serine synthesis. CBR-5884 (15 or 30 μM; 3-5 days) also selectively inhibits the proliferation of melanoma.

Chemical Properties

Molecular Weight	336.39
Formula	C14H12N2O4S2
Cas No.	681159-27-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 47 mg/mL (139.72 mM)

H2O: < 0.1 mg/mL (insoluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9727 mL	14.8637 mL	29.7274 mL	148.6370 mL
5 mM	0.5945 mL	2.9727 mL	5.9455 mL	29.7274 mL
10 mM	0.2973 mL	1.4864 mL	2.9727 mL	14.8637 mL
20 mM	0.1486 mL	0.7432 mL	1.4864 mL	7.4318 mL
50 mM	0.0595 mL	0.2973 mL	0.5945 mL	2.9727 mL
100 mM	0.0297 mL	0.1486 mL	0.2973 mL	1.4864 mL

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