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DCLX069

DCLX069 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 value of 17.9 µM, occupying the SAM binding pocket to exert its inhibitory effect. It effectively blocks cell proliferation in breast cancer, liver cancer, and acute myeloid leukemia cell lines.

Catalog No. T27133Cas No. 792946-69-1

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Purity:98.06%

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COA HNMR HPLC

DCLX069

Catalog No. T27133Cas No. 792946-69-1

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Pack Size	Price	Availability
1 mg	$32	In Stock
2 mg	$45	In Stock
5 mg	$72	In Stock
10 mg	$113	In Stock
25 mg	$196	In Stock
50 mg	$322	In Stock
100 mg	$513	In Stock
500 mg	$1,090	In Stock
1 mL x 10 mM (in DMSO)	$84	In Stock

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Product Introduction

Bioactivity

Description	DCLX069 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 value of 17.9 µM, occupying the SAM binding pocket to exert its inhibitory effect. It effectively blocks cell proliferation in breast cancer, liver cancer, and acute myeloid leukemia cell lines.
Targets&IC50	PRMT1:17.9 μM (IC50)
Alias	DCLX 069, DCLX-069

Chemical Properties

Molecular Weight	339.43
Formula	C₂₀H₂₅N₃O₂
Cas No.	792946-69-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 60 mg/ml (176.77 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9461 mL	14.7306 mL	29.4612 mL	147.3058 mL
5 mM	0.5892 mL	2.9461 mL	5.8922 mL	29.4612 mL
10 mM	0.2946 mL	1.4731 mL	2.9461 mL	14.7306 mL
20 mM	0.1473 mL	0.7365 mL	1.4731 mL	7.3653 mL
50 mM	0.0589 mL	0.2946 mL	0.5892 mL	2.9461 mL
100 mM	0.0295 mL	0.1473 mL	0.2946 mL	1.4731 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc