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PF07104091
🥰Excellent
Catalog No. T9712Cas No. 2460249-19-6
Alias PF-07104091
PF07104091 inhibits CDK2, which may lead to cell cycle arrest, induce apoptosis and inhibit tumor cell proliferation.[1]
PF07104091
🥰Excellent
Purity: 98.61%
Catalog No. T9712Alias PF-07104091Cas No. 2460249-19-6
PF07104091 inhibits CDK2, which may lead to cell cycle arrest, induce apoptosis and inhibit tumor cell proliferation.[1]
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $372 | In Stock | |
| 2 mg | $546 | In Stock | |
| 5 mg | $867 | In Stock | |
| 10 mg | $1,270 | In Stock | |
| 25 mg | $1,890 | In Stock | |
| 50 mg | $2,550 | In Stock | |
| 100 mg | $3,430 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $963 | In Stock |
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Purity:98.61%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PF07104091 inhibits CDK2, which may lead to cell cycle arrest, induce apoptosis and inhibit tumor cell proliferation.[1] |
| In vitro | PF-07104091 hydrate (Example 13) inhibits CDK1/cyclin A2, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9, with Kis of 110, 238, 465 and 117 nM.[1] METHODS: We explored whether CDK2 activity could be completely abolished by pharmacological treatment with supraphysiological doses of PF3600 (10 μM) or PF4091 (20 μM). RESULTS We observed an immediate collapse of the DHB reporter signal below the mitotic nadir, without a hump. [2] |
| Alias | PF-07104091 |
| Molecular Weight | 404.46 |
| Formula | C19H28N6O4 |
| Cas No. | 2460249-19-6 |
| Smiles | N(C(=O)C1=CC(COC)=NN1C)C2=CC(=NN2)[C@@H]3C[C@H](OC(NC(C)C)=O)CC3 |
| Relative Density. | 1.38 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (135.98 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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