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CD98 Protein, Human, Recombinant (mFc)

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CD98 Protein, Human, Recombinant (mFc)

Catalog No. TMPJ-00352

CD98 is a multifunctional glycoprotein that is involved in various biological processes such as amino acid transport, cell adhesion, diffusion, adhesion, and proliferation. CD98 can interact with CD147 to induce integrin 1 function to promote cyclosporine B-induced cell adhesion and p44/p42 MAPK activation following PI3K activation. CD98 heavy chain has been studied to be a key player in tumorigenesis due to its role in activating integrin signaling to promote tumor progression via angiogenesis, invasiveness, and proliferation in addition to promoting malignant transformation of cells. Fibrotic progression in the liver could be linked to the activation of integrin αvβ1 via CD98. CD98’s role in T cell activation in which the TGF activation could also play a profibrotic role.

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Pack Size	Price	Availability
10 μg	$64	7-10 days
50 μg	$200	7-10 days
500 μg	$1,570	7-10 days
1 mg	$2,370	7-10 days

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Biological Description

Biological Information	1. Loaded Anti-Human CD98 mAb-Fc on AHC Biosensor, can bind Human CD98-mFc with an affinity constant of <10^-3 nM as determined in BLI assay. (Regularly tested) 2. Immobilized Human CD98-mFc at 2μg/ml (100 μl/well) can bind Anti-Human CD98 mAb . The ED50 of Anti-Human CD98 mAb is 1.34 ng/ml. (Regularly tested)
Description	CD98 is a multifunctional glycoprotein that is involved in various biological processes such as amino acid transport, cell adhesion, diffusion, adhesion, and proliferation. CD98 can interact with CD147 to induce integrin 1 function to promote cyclosporine B-induced cell adhesion and p44/p42 MAPK activation following PI3K activation. CD98 heavy chain has been studied to be a key player in tumorigenesis due to its role in activating integrin signaling to promote tumor progression via angiogenesis, invasiveness, and proliferation in addition to promoting malignant transformation of cells. Fibrotic progression in the liver could be linked to the activation of integrin αvβ1 via CD98. CD98’s role in T cell activation in which the TGF activation could also play a profibrotic role.
Species	Human
Expression System	HEK293 Cells
Tag	N-mFc
Accession Number	P08195
Synonyms	Lymphocyte activation antigen 4F2 large subunit,4F2 cell-surface antigen heavy chain,CD98,MDU1,SLC3A2,4F2hc,Solute carrier family 3 member 2
Amino Acid	Arg206-Ala630
Construction	Arg206-Ala630
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight	70-100 KDa (reducing condition)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH7.4.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	CD98 is a multifunctional glycoprotein that is involved in various biological processes such as amino acid transport, cell adhesion, diffusion, adhesion, and proliferation. CD98 can interact with CD147 to induce integrin 1 function to promote cyclosporine B-induced cell adhesion and p44/p42 MAPK activation following PI3K activation. CD98 heavy chain has been studied to be a key player in tumorigenesis due to its role in activating integrin signaling to promote tumor progression via angiogenesis, invasiveness, and proliferation in addition to promoting malignant transformation of cells. Fibrotic progression in the liver could be linked to the activation of integrin αvβ1 via CD98. CD98’s role in T cell activation in which the TGF activation could also play a profibrotic role.