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AUNP-12 acetate
🥰Excellent
Catalog No. TP1076L
Alias AUNP-12 acetate (1353563-85-5 Free base)
AUNP-12 acetate is a polypeptide inhibitor of PD-1 that is equivalent to PD-1 and PD-2 in inhibiting lymphocyte proliferation and effector fuction, in addition to immune activation and antitumor activity.
AUNP-12 acetate
🥰Excellent
Purity: 95.07%
Catalog No. TP1076LAlias AUNP-12 acetate (1353563-85-5 Free base)
AUNP-12 acetate is a polypeptide inhibitor of PD-1 that is equivalent to PD-1 and PD-2 in inhibiting lymphocyte proliferation and effector fuction, in addition to immune activation and antitumor activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 110 € | In Stock | |
| 5 mg | 309 € | In Stock | |
| 10 mg | 464 € | In Stock | |
| 25 mg | 758 € | In Stock | |
| 50 mg | 1.035 € | In Stock | |
| 100 mg | 1.406 € | In Stock |
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Purity:95.07%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | AUNP-12 acetate is a polypeptide inhibitor of PD-1 that is equivalent to PD-1 and PD-2 in inhibiting lymphocyte proliferation and effector fuction, in addition to immune activation and antitumor activity. |
| In vitro | In vitro, AUNP-12 displayed equipotent antagonism toward PD-L1 and PD-L2 in the rescue of lymphocyte proliferation and effector functions. In human PBMC cells, AUNP-12 was also able to significantly rescue recombinant human PD-L1 and PD-L2 mediated inhibition in vitro, with average EC50 values of 63.3 nM and 44.1 nM against PD-L1 and PD-L2 respectively. [1] |
| In vivo | AUNP-12 acetate rescued the proliferation in the mouse splenocyte assay system, with average EC50 values of 17 nM and 16.6 nM against rmPD-L1 and rmPD-L2 respectively. AUNP-12 (6 hours) showed a Plasma protein binding of 93.9% with plasma stability of more than 60%. AUNP-12 exhibited a half-life of 90 minutes in mouse liver microsomes. In male Balb/c mice, AUNP-12 subcutaneous injection or intravenous injection as a concentration of 3 mg/kg for its PK study. As a result, AUNP-12 shows a low volume of distribution, and the peak plasma levels reach at 0.2-0.4 hours. The absolute bioavailability of AUNP-12 is about 77% in mice. [1] |
| Alias | AUNP-12 acetate (1353563-85-5 Free base) |
| Molecular Weight | 3321.61 |
| Formula | C144H230N40O50 |
| Smiles | O=C([C@@](C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])([H])N([H])C([C@](C([H])([H])[H])([H])N([H])C([C@@](C([H])([H])C([H])([H])C(N([H])[H])=O)([H])N([H])C([C@@]([C@@](C([H])([H])[H])([H])C([H])([H])C([H])([H])[H])([H])N([H])C([C@@](C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])([H])N([H])C([C@@](C([H])([H])C([H])([H])C(O[H])=O)([H])N([H])N([H])[H])=O)=O)=O)=O)=O)N1[C@@](C(N([H])[C@](C(C([C@@](C([H])([H])C(C([H])([H])[H])([H])C([H])([H])[H])([H])N([H])C([C@@](C([H])([H])C([H])([H])C(N([H])[H])=O)([H])N([H])C([C@@]([C@@](C([H])([H])[H])([H])O[H])([H])N([H])C([C@@](C(C([H])([H])[H])([H])C([H])([H])[H])([H])N([H])C([C@@](C([H])([H])C([H])([H])C([H])([H])N([H])/C(N([H])[H])=N/[H])([H])N([H])C([C@@](C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])([H])N([H])C(C(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])N([H])[C@@](C(N([H])[C@](C([H])([H])O[H])([H])C(N([H])[C@@](C(N([H])[C@](C([H])([H])O[H])([H])C(N([H])[C@@](C(N([H])[C@@](C(N([H])[C@@](C([H])=O)([H])C([H])([H])O[H])=O)([H])C([H])([H])C(N([H])[H])=O)=O)([H])[C@@](C([H])([H])[H])([H])O[H])=O)=O)([H])C([H])([H])C([H])([H])C(O[H])=O)=O)=O)([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])([H])N([H])C([C@@](C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])([H])N([H])C([C@@](C([H])([H])O[H])([H])N([H])C([C@@](C([H])([H])C([H])([H])C(O[H])=O)([H])N([H])C([C@@](C([H])([H])O[H])([H])N([H])C([C@@]([C@@](C([H])([H])[H])([H])O[H])([H])N([H])C([C@@](C([H])([H])C(N([H])[H])=O)([H])N([H])C([C@@](C([H])([H])O[H])([H])N([H])[H])=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)([H])C([H])([H])[H])=O)([H])C([H])([H])C([H])([H])C1([H])[H].CC(O)=O |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (30.11 mM), Sonication is recommended.  H2O: 25 mg/mL (7.53 mM), Sonification is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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