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PD-L1-IN-3
🥰Excellent
Catalog No. T79314Cas No. 2953044-29-4
PD-L1-IN-3 (Compound 4a) functions as an inhibitor of the PD-1/PD-L1 axis, with an IC50 value of 4.97 nM for PD-L1 inhibition and an EC50 value of 2.70 μM for Jurkat T cell modulation. It antagonizes the PD-1/PD-L1 interaction by binding to the PD-L1 dimer, obstructing PD-1 signaling. This compound is utilized in research pertaining to lung cancer and melanoma [1].
PD-L1-IN-3
🥰Excellent
Purity: 99.47%
Catalog No. T79314Cas No. 2953044-29-4
PD-L1-IN-3 (Compound 4a) functions as an inhibitor of the PD-1/PD-L1 axis, with an IC50 value of 4.97 nM for PD-L1 inhibition and an EC50 value of 2.70 μM for Jurkat T cell modulation. It antagonizes the PD-1/PD-L1 interaction by binding to the PD-L1 dimer, obstructing PD-1 signaling. This compound is utilized in research pertaining to lung cancer and melanoma [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $90 | In Stock | |
| 5 mg | $222 | In Stock | |
| 10 mg | $355 | In Stock | |
| 25 mg | $689 | In Stock | |
| 50 mg | $1,090 | In Stock | |
| 100 mg | $1,730 | In Stock |
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Purity:99.47%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PD-L1-IN-3 (Compound 4a) functions as an inhibitor of the PD-1/PD-L1 axis, with an IC50 value of 4.97 nM for PD-L1 inhibition and an EC50 value of 2.70 μM for Jurkat T cell modulation. It antagonizes the PD-1/PD-L1 interaction by binding to the PD-L1 dimer, obstructing PD-1 signaling. This compound is utilized in research pertaining to lung cancer and melanoma [1]. |
| In vitro | PD-L1-IN-3 (Compound 4a) disrupts the PD-1 and PD-L1 interaction at concentrations of 0.01 to 100 μM over 40 minutes, enhancing TCR-mediated activation of Jurkat cells [1]. Additionally, PD-L1-IN-3 demonstrates increased uptake in PD-L1-positive H358 tumors, proportional to PD-L1 expression levels [1]. |
| In vivo | In PD-L1+/− (H358 and ES2) tumors, PD-L1-IN-3 (0.01-100 μM; incubation) was observed to exhibit 40-55% higher uptake in PD-L1+ H358 tumors compared to wild-type counterparts. However, it failed to distinguish between wild-type and knockout ES2 samples[1]. |
| Molecular Weight | 373.85 |
| Formula | C19H15ClFN2OS |
| Cas No. | 2953044-29-4 |
| Smiles | [Cl].N#CC1=C(OCC2=CC=C(C=C2)CN)SC=C1C=3C=CC(F)=CC3 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL 266.77 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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