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BMS-1
🥰Excellent
Catalog No. T3655Cas No. 1675201-83-8
Alias PD1-PDL1 inhibitor 1, PD-1/PD-L1 inhibitor 1
BMS-1 (PD-1/PD-L1 inhibitor 1) is an inhibitor of the PD1-PD-L1 protein-protein interaction. It also acts as an immunomodulator. Programmed death ligand 1 (PD-L1) is a protein in humans that is encoded by the CD274 gene and the upregulation of PD-L1 allows Ys to evade the host immune system. High tumor expression of PD-L1 was associated with increased tumor aggressiveness and a 4.5-fold increased risk of death.
BMS-1
🥰Excellent
Purity: 99.86%
Catalog No. T3655Alias PD1-PDL1 inhibitor 1, PD-1/PD-L1 inhibitor 1Cas No. 1675201-83-8
BMS-1 (PD-1/PD-L1 inhibitor 1) is an inhibitor of the PD1-PD-L1 protein-protein interaction. It also acts as an immunomodulator. Programmed death ligand 1 (PD-L1) is a protein in humans that is encoded by the CD274 gene and the upregulation of PD-L1 allows Ys to evade the host immune system. High tumor expression of PD-L1 was associated with increased tumor aggressiveness and a 4.5-fold increased risk of death.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 45 € | In Stock | |
| 2 mg | 66 € | In Stock | |
| 5 mg | 106 € | In Stock | |
| 10 mg | 177 € | In Stock | |
| 25 mg | 332 € | In Stock | |
| 50 mg | 477 € | In Stock | |
| 100 mg | 696 € | In Stock | |
| 500 mg | 1.453 € | In Stock |
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Purity:99.86%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | BMS-1 (PD-1/PD-L1 inhibitor 1) is an inhibitor of the PD1-PD-L1 protein-protein interaction. It also acts as an immunomodulator. Programmed death ligand 1 (PD-L1) is a protein in humans that is encoded by the CD274 gene and the upregulation of PD-L1 allows Ys to evade the host immune system. High tumor expression of PD-L1 was associated with increased tumor aggressiveness and a 4.5-fold increased risk of death. |
| Targets&IC50 | PD-1/PD-L1:0.006 μM |
| Alias | PD1-PDL1 inhibitor 1, PD-1/PD-L1 inhibitor 1 |
| Molecular Weight | 475.58 |
| Formula | C29H33NO5 |
| Cas No. | 1675201-83-8 |
| Smiles | COc1cc(OCc2cccc(c2C)-c2ccccc2)cc(OC)c1CN1CCCC[C@H]1C(O)=O |
| Relative Density. | 1.182 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.76 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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