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Immuno-Oncology Compound Library

Catalog No. L2170
  Library Compound List   Excel SDF

Traditional cancer therapies include surgery, radiation therapy, and chemotherapy. With the rapid development of science and technology in medicine, new cancer therapies such as immunotherapy, targeted therapy, radiofrequency ablation for cancer are actively developed to help patients fight cancer. Cancer immunotherapy, also known as immuno-oncology, is a form of cancer treatment that uses the power of the body’s own immune system to prevent, control, and eliminate cancer. Science magazine—America’s leading scientific journal—has deemed cancer immunotherapy the 2013 “Breakthrough of the Year,” beating out nine other contenders.

There are several types of immunotherapy, including: Non-specific immunotherapies, CAR T-cell therapy, cancer vaccines, checkpoint inhibitors, etc. Most cancer immunotherapy agents being developed or approved are engineered T cells targeting tumors or mostly antibody-based biologics that target the immune checkpoint cascade. The success of these biologics in the clinic is now inspiring the discovery and development of small molecules that act on intracellular targets affecting immuno-modulatory pathways in cancer. Small molecule agents as opposed to biologics that steer or enable the immune system to attack cancer cells, represent an emerging area of R&D focus in the oncology drug development industry. Small molecules are being investigated as stand-alone agents and synergistically with approved biologics because of the ability of small molecules to reach intracellular targets and the greater patient convenience offered by their oral bioavailability. The foundation for the pursuit of small molecule immune therapies for cancer is the wide spectrum of cells and their molecular pathways that are used by the immune system to suppress or enhance cellular immunity. Such novel immunotherapeutic approaches can either negate immune suppression in the tumor milieu or facilitate cytolytic lymphocyte responses to the tumor.

TargetMol’s Immuno-Oncology Compound Library carefully collects 454 bioactive compounds targeting intracellular pathways modulating the innate and adaptive immune response is a powerful tool for your research and drug discovery.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
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Product Description

  • A unique collection of 454 compounds acting on immune-oncology therapeutic targets can be used for high throughput and high content screening;
  • Targets include PD-1/PD-L1, HER2, STAT3, CTLA4, IDO, STING, CCR, CXCR, TLR, etc.
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L2170)

Library Composition

TNF (77)
PI3K (55)
STAT (43)
TLR (41)
CXCR (31)
CCR (23)
IL Receptor (23)
EGFR (22)
HER (18)
NF-κB (18)
TGF-beta/Smad (16)
IDO (16)
Adenosine Receptor (14)
ALK (13)
mTOR (13)
BTK (13)
STING (12)
VEGFR (10)
JAK (8)
p38 MAPK (7)
DNA-PK (7)
Epigenetic Reader Domain (7)
CSF-1R (7)
COX (6)
PD-1/PD-L1 (6)
FLT (6)
HIV Protease (5)
Autophagy (5)
Arginase (5)
ERK (5)
Src (5)
c-Met/HGFR (5)
PDGFR (5)
c-Fms (4)
Raf (4)
PDE (4)
NOD (3)
ROS (3)
Akt (3)
5-HT Receptor (3)
MEK (3)
c-Kit (3)
Casein Kinase (3)
Tyrosine Kinases (3)
FGFR (3)
MMP (2)
HDAC (2)
Carbonic Anhydrase (2)
Caspase (2)
CDK (2)
NOS (2)
Tyrosinase (2)
Bcr-Abl (2)
DNA/RNA Synthesis (2)
Apoptosis (2)
Beta Amyloid (2)
Antioxidant (2)
Indoleamine 2,3-Dioxygenase (IDO) (2)
AChR (2)
MAPK (2)
LTR (2)
Adrenergic Receptor (2)
IκB/IKK (2)
HSP (2)
Antibacterial (2)
Sirtuin (1)
Tie-2 (1)
Potassium Channel (1)
PPAR (1)
PTEN (1)
PKM (1)
VDA (1)
SARS-CoV (1)
Syk (1)
UGT (1)
transporter (1)
TRP/TRPV Channel (1)
S6 Kinase (1)
TAM Receptor (1)
Trk receptor (1)
Antifection (1)
PKC (1)
ACK (1)
CFTR (1)
Chloride channel (1)
c-Myc (1)
Cysteine Protease (1)
Decarboxylase (1)
DHFR (1)
DNA Alkylation (1)
HIF (1)
JNK (1)
MLK (1)
MNK (1)
Amino Acids and Derivatives (1)
PKA (1)
AMPK (1)
Antibiotic (1)
Antiviral (1)
BCL (1)
NADPH-oxidase (1)
NAMPT (1)
NO Synthase (1)
Nrf2 (1)
P450 (1)
PGE Synthase (1)
P-gp (1)
Phosphatase (1)
Wnt/beta-catenin (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE