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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $588 | In Stock | |
2 mg | $843 | In Stock | |
5 mg | $1,280 | In Stock | |
10 mg | $1,730 | In Stock | |
25 mg | $2,570 | In Stock | |
50 mg | $3,380 | In Stock |
Description | KW-2450 free base is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 free base selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis. |
Molecular Weight | 515.63 |
Formula | C28H29N5O3S |
Cas No. | 904899-25-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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