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ALK-IN-1

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Purity:100%

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COA LCMS HNMR

ALK-IN-1

Catalog No. T3059Cas No. 1197958-12-5

ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2.

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Pack Size	Price	Availability
5 mg	$40	In Stock
10 mg	$64	In Stock
25 mg	$97	In Stock
50 mg	$147	In Stock
100 mg	$247	In Stock
200 mg	$367	In Stock
500 mg	$595	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock

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Product Introduction

Bioactivity

Description	ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2.
Cell Research	Three-day cell viability assays are carried out by plating 2,000, 1,500 and 2,000 cells per well of Ba/F3, PC9 or MGH121, respectively, into black transparent-bottom 96-well plates. On the same day for Ba/F3 cells and the following day for PC9 and MGH121 cells, the cells are treated with each TKI across a 10-dose range from 0.3 nM to 10 μM. After 72 h of drug treatment, cell viability is measured using the CellTiter-Glo assay. (Only for Reference)
Alias	AP26113, Brigatinib, AP26113-analog

Chemical Properties

Molecular Weight	529.01
Formula	C26H34ClN6O2P
Cas No.	1197958-12-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 98 mg/mL (185.3 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 1mg/ml

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.8903 mL	9.4516 mL	18.9032 mL	94.5162 mL
5 mM	0.3781 mL	1.8903 mL	3.7806 mL	18.9032 mL
10 mM	0.1890 mL	0.9452 mL	1.8903 mL	9.4516 mL
20 mM	0.0945 mL	0.4726 mL	0.9452 mL	4.7258 mL
50 mM	0.0378 mL	0.1890 mL	0.3781 mL	1.8903 mL
100 mM	0.0189 mL	0.0945 mL	0.1890 mL	0.9452 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc