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JDB175
😃Good
Catalog No. T82010Cas No. 2635328-79-7
JDB175, a selective BTK inhibitor with oral bioavailability, demonstrates excellent penetration through the blood-brain barrier. It exhibits potent activity against central nervous system lymphoma in a mouse model, with no apparent toxicity. JDB175 effectively suppresses human lymphoma cell proliferation by inhibiting the BTK signaling pathway, induces cell cycle arrest, and promotes apoptosis[1].
JDB175
😃Good
Catalog No. T82010Cas No. 2635328-79-7
JDB175, a selective BTK inhibitor with oral bioavailability, demonstrates excellent penetration through the blood-brain barrier. It exhibits potent activity against central nervous system lymphoma in a mouse model, with no apparent toxicity. JDB175 effectively suppresses human lymphoma cell proliferation by inhibiting the BTK signaling pathway, induces cell cycle arrest, and promotes apoptosis[1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | JDB175, a selective BTK inhibitor with oral bioavailability, demonstrates excellent penetration through the blood-brain barrier. It exhibits potent activity against central nervous system lymphoma in a mouse model, with no apparent toxicity. JDB175 effectively suppresses human lymphoma cell proliferation by inhibiting the BTK signaling pathway, induces cell cycle arrest, and promotes apoptosis[1]. |
| In vitro | DB175, at concentrations ranging from 15-40 μM administered over 48 hours, effectively inhibits the phosphorylation of BTK and downregulates the expression of cyclin D1 and CDK2, while upregulating the expression of P21 in Namalwa and Raji cells [1]. |
| In vivo | JDB175 administered at a dose of 10 mg/kg orally (口服) and observed for 0.5 hours demonstrates a strong potential to permeate the blood-brain barrier and effectively suppresses central nervous system lymphoma in rats [1]. When given to nude mouse models of central nervous system lymphoma at a higher dosage of 150 mg/kg orally (口服) over three days, JDB175 effectively inhibits tumor growth while maintaining a favorable safety profile [1]. |
| Molecular Weight | 478.47 |
| Formula | C26H21F3N4O2 |
| Cas No. | 2635328-79-7 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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