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Butyzamide
Butyzamide is an effective and oral Mpl activator. It is a novel non-peptide-based molecule with antagonistic effects on thrombopoietin (TPO) receptors, which promotes proliferation of human Mpl (hMpl) expression and mouse pro B cell line Ba/F3. The phosphorylation of JAK2, STAT3, STAT5 and MAPK is induced. Butyzamide has been shown to help increase platelet levels in mouse xenotransplantation trials.
Catalog No. T67894Cas No. 1110767-45-7
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Butyzamide
Catalog No. T67894Cas No. 1110767-45-7
Butyzamide is an effective and oral Mpl activator. It is a novel non-peptide-based molecule with antagonistic effects on thrombopoietin (TPO) receptors, which promotes proliferation of human Mpl (hMpl) expression and mouse pro B cell line Ba/F3. The phosphorylation of JAK2, STAT3, STAT5 and MAPK is induced. Butyzamide has been shown to help increase platelet levels in mouse xenotransplantation trials.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $285 | In Stock | |
| 5 mg | $687 | In Stock | |
| 10 mg | $998 | In Stock | |
| 25 mg | $1,480 | In Stock | |
| 50 mg | $1,990 | In Stock | |
| 100 mg | $2,690 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Butyzamide is an effective and oral Mpl activator. It is a novel non-peptide-based molecule with antagonistic effects on thrombopoietin (TPO) receptors, which promotes proliferation of human Mpl (hMpl) expression and mouse pro B cell line Ba/F3. The phosphorylation of JAK2, STAT3, STAT5 and MAPK is induced. Butyzamide has been shown to help increase platelet levels in mouse xenotransplantation trials. |
| In vitro | Butyzamide (3 μM; 15 minutes) induces phosphorylation of JAK2, STAT3, STAT5, and MAPK in Ba/F3-hMpl cells.[1] Butyzamide (3 μM; 48 hours) induces colony-forming unit-megakaryocyte (CFU-MK) and polyploid megakaryocyte formation in human CD34+ hematopoietic progenitor cells.[1] |
| In vivo | Butyzamide (10 mg/kg, 50 mg/kg; oral administration; once daily for 20 days) enhances human platelet levels in NOG mice transplanted with human fetal liver-derived CD34+ cells.[1] |
| Molecular Weight | 591.55 |
| Formula | C29H32Cl2N2O5S |
| Cas No. | 1110767-45-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 225.0 mg/mL (751.7 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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