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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $42 | In Stock | |
5 mg | $98 | In Stock | |
10 mg | $150 | In Stock | |
25 mg | $198 | In Stock | |
50 mg | $297 | In Stock | |
100 mg | $455 | In Stock |
Description | MIF098, a macrophage migration inhibitory factor (MIF) antagonist, inhibits pulmonary hypertension associated with SLE and the proliferation and migration of pulmonary arterial smooth muscle cells (PASMC). MIF098 may also be used to study idiopathic pulmonary hypertension. |
In vitro | In a concentration-dependent manner, MIF098 (0-10 μM, 48 h) inhibits mPASMC cell proliferation and migration by blocking the migration inhibitory factor (MIF) pathway[1].By inhibiting the TGFβ1/Smad2/3 pathway, MIF098 reduces collagen synthesis and pulmonary artery fibrosis [1]. |
In vivo | Administered through intraperitoneal injection at a dose of 40 mg/kg once a day for 4 weeks, MIF098 attenuates the progression of hypoxia-induced pulmonary arterial hypertension in C57BL/6J mice [1]. |
Molecular Weight | 255.27 |
Formula | C15H13NO3 |
Cas No. | 1208448-95-6 |
Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (313.39 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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