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MIF098

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Purity:99.9%

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COA HPLC HNMR

MIF098

Catalog No. T60388Cas No. 1208448-95-6

MIF098, a macrophage migration inhibitory factor (MIF) antagonist, inhibits pulmonary hypertension associated with SLE and the proliferation and migration of pulmonary arterial smooth muscle cells (PASMC). MIF098 may also be used to study idiopathic pulmonary hypertension.

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Pack Size	Price	Availability
1 mg	$42	In Stock
5 mg	$98	In Stock
10 mg	$150	In Stock
25 mg	$198	In Stock
50 mg	$297	In Stock
100 mg	$455	In Stock

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Product Introduction

Bioactivity

Description	MIF098, a macrophage migration inhibitory factor (MIF) antagonist, inhibits pulmonary hypertension associated with SLE and the proliferation and migration of pulmonary arterial smooth muscle cells (PASMC). MIF098 may also be used to study idiopathic pulmonary hypertension.
In vitro	In a concentration-dependent manner, MIF098 (0-10 μM, 48 h) inhibits mPASMC cell proliferation and migration by blocking the migration inhibitory factor (MIF) pathway[1].By inhibiting the TGFβ1/Smad2/3 pathway, MIF098 reduces collagen synthesis and pulmonary artery fibrosis [1].
In vivo	Administered through intraperitoneal injection at a dose of 40 mg/kg once a day for 4 weeks, MIF098 attenuates the progression of hypoxia-induced pulmonary arterial hypertension in C57BL/6J mice [1].

Chemical Properties

Molecular Weight	255.27
Formula	C15H13NO3
Cas No.	1208448-95-6

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (313.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9174 mL	19.5871 mL	39.1742 mL	195.8710 mL
5 mM	0.7835 mL	3.9174 mL	7.8348 mL	39.1742 mL
10 mM	0.3917 mL	1.9587 mL	3.9174 mL	19.5871 mL
20 mM	0.1959 mL	0.9794 mL	1.9587 mL	9.7936 mL
50 mM	0.0783 mL	0.3917 mL	0.7835 mL	3.9174 mL
100 mM	0.0392 mL	0.1959 mL	0.3917 mL	1.9587 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc