α-Solanine (alpha-Solanine) is an alkaloid derived from potato with anticancer and antitumor activity, attenuating chondrocyte death by inhibiting the NF-κB pathway. α-Solanine inhibits the proliferation and migration of glioma cells but promotes apoptosis of glioma cells.

METHODS: α-solanine (3, 6, 9, 12 μg/μl) was used to treat PANC-1, sw1990 and MIA PaCa-2 cells for 24 h or 48 h, and the viability of cells was observed.
RESULTS: After treatment with α-solanine (12 μg/μl), the cell viability was significantly decreased. At α-solanine concentrations of 3, 6, and 9 μg/μl, and treatment time of 24 h and 48 h, α-solanine did not cause cytotoxicity in the cells of each cell line.
α-Solanine (3, 6 and 9 μg/μl) significantly reduced the mRNA and protein expression of VEGF in PANC-1 cells in a dose-dependent manner, while α-solanine inhibited angiogenesis by inhibiting VEGF expression.[1]

METHODS: 1 μl/g of α-solanine was injected into the peritoneal cavity of each mouse for two weeks. The body weight of the mice and the size of their tumors were measured daily.
RESULTS: α-solanine inhibited the growth of PANC-1 tumor xenografts, reducing tumor volume by 61% (P<0.05). [1]