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α-Solanine
🥰Excellent
Catalog No. TN1376Cas No. 20562-02-1
Alias alpha-Solanine
α-Solanine (alpha-Solanine) is an alkaloid derived from potato with anticancer and antitumor activity, attenuating chondrocyte death by inhibiting the NF-κB pathway. α-Solanine inhibits the proliferation and migration of glioma cells but promotes apoptosis of glioma cells.
α-Solanine
🥰Excellent
Purity: 99.37%
Catalog No. TN1376Alias alpha-SolanineCas No. 20562-02-1
α-Solanine (alpha-Solanine) is an alkaloid derived from potato with anticancer and antitumor activity, attenuating chondrocyte death by inhibiting the NF-κB pathway. α-Solanine inhibits the proliferation and migration of glioma cells but promotes apoptosis of glioma cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $68 | In Stock | |
| 5 mg | $172 | In Stock | |
| 10 mg | $272 | In Stock | |
| 25 mg | Inquiry | In Stock | |
| 1 mL x 10 mM (in DMSO) | $266 | In Stock |
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CitedSelect Batch
Purity:99.37%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | α-Solanine (alpha-Solanine) is an alkaloid derived from potato with anticancer and antitumor activity, attenuating chondrocyte death by inhibiting the NF-κB pathway. α-Solanine inhibits the proliferation and migration of glioma cells but promotes apoptosis of glioma cells. |
| In vitro | METHODS: α-solanine (3, 6, 9, 12 μg/μl) was used to treat PANC-1, sw1990 and MIA PaCa-2 cells for 24 h or 48 h, and the viability of cells was observed. RESULTS: After treatment with α-solanine (12 μg/μl), the cell viability was significantly decreased. At α-solanine concentrations of 3, 6, and 9 μg/μl, and treatment time of 24 h and 48 h, α-solanine did not cause cytotoxicity in the cells of each cell line. α-Solanine (3, 6 and 9 μg/μl) significantly reduced the mRNA and protein expression of VEGF in PANC-1 cells in a dose-dependent manner, while α-solanine inhibited angiogenesis by inhibiting VEGF expression.[1] |
| In vivo | METHODS: 1 μl/g of α-solanine was injected into the peritoneal cavity of each mouse for two weeks. The body weight of the mice and the size of their tumors were measured daily. RESULTS: α-solanine inhibited the growth of PANC-1 tumor xenografts, reducing tumor volume by 61% (P<0.05). [1] |
| Alias | alpha-Solanine |
| Molecular Weight | 868.06 |
| Formula | C45H73NO15 |
| Cas No. | 20562-02-1 |
| Smiles | C[C@@H]1[C@H]2CC[C@H](C)CN2[C@H]2C[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]3(C)[C@@H]12)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]1O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O |
| Relative Density. | 1.40 g/cm3 at 20℃ |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (34.56 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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