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SJF 1528

Catalog No. T36245Cas No. 2230821-38-0

Potent EGFR Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells). Also degrades HER2. Comprises the EGFR inhibitor lapatinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells).

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Pack Size	Price	Availability	Quantity
5 mg	$987	35 days

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Product Introduction

Bioactivity

Description

Potent EGFR Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells). Also degrades HER2. Comprises the EGFR inhibitor lapatinib (Cat. No. 6811) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells).

Chemical Properties

Molecular Weight	1030.61
Formula	C55H57ClFN7O8S
Cas No.	2230821-38-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 103.06 mg/mL(100 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9703 mL	4.8515 mL	9.7030 mL	48.5150 mL
5 mM	0.1941 mL	0.9703 mL	1.9406 mL	9.7030 mL
10 mM	0.0970 mL	0.4851 mL	0.9703 mL	4.8515 mL
20 mM	0.0485 mL	0.2426 mL	0.4851 mL	2.4257 mL
50 mM	0.0194 mL	0.0970 mL	0.1941 mL	0.9703 mL
100 mM	0.0097 mL	0.0485 mL	0.0970 mL	0.4851 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SJF1528SJF-1528SJF 1528