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AMPK activator 11

AMPK activator 11
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AMPK activator 11

Catalog No. T79226Cas No. 2948304-00-3
AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-activated protein kinase (AMPK) and enhancement of oxidative phosphorylation (OXPHOS) (mitochondrial metabolism). This compound demonstrates particular efficacy in inhibiting RKO xenograft growth, rendering it useful for anti-tumor and metabolic disease research [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-activated protein kinase (AMPK) and enhancement of oxidative phosphorylation (OXPHOS) (mitochondrial metabolism). This compound demonstrates particular efficacy in inhibiting RKO xenograft growth, rendering it useful for anti-tumor and metabolic disease research [1].
In vitro
AMPK activator 11 (Compound 18a) at 0-30 μM for 0-7 days inhibits growth and migration of CRC cells with an IC50 value below 1 μM [1]. When administered at 0-0.1 μM for 24 hours, it significantly increases the oxygen consumption rate (OCR) in RKO cells, while causing minimal changes in the extracellular acidification rate (ECAR). Additionally, AMPK activator 11 upregulates the expression of p-AMPK and mitochondrial complexes III and V, indicating a selective activation capability of OXPHOS in CRC [1].
In vivo
AMPK activator 11 (Compound 18a) at doses of 2.5 or 10 mg/kg was administered intraperitoneally for 25 days and selectively inhibited tumor growth in an RKO cell xenograft model in vitro without toxicity [1].
Chemical Properties
Molecular Weight408.45
FormulaC25H20N4O2
Cas No.2948304-00-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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