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AMPK activator 11
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Catalog No. T79226Cas No. 2948304-00-3
AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-activated protein kinase (AMPK) and enhancement of oxidative phosphorylation (OXPHOS) (mitochondrial metabolism). This compound demonstrates particular efficacy in inhibiting RKO xenograft growth, rendering it useful for anti-tumor and metabolic disease research [1].
AMPK activator 11
😃Good
Catalog No. T79226Cas No. 2948304-00-3
AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-activated protein kinase (AMPK) and enhancement of oxidative phosphorylation (OXPHOS) (mitochondrial metabolism). This compound demonstrates particular efficacy in inhibiting RKO xenograft growth, rendering it useful for anti-tumor and metabolic disease research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-activated protein kinase (AMPK) and enhancement of oxidative phosphorylation (OXPHOS) (mitochondrial metabolism). This compound demonstrates particular efficacy in inhibiting RKO xenograft growth, rendering it useful for anti-tumor and metabolic disease research [1]. |
| In vitro | AMPK activator 11 (Compound 18a) inhibits the growth and migration of CRC cells with an IC50 below 1 μM at 0-30 μM for 0-7 days [1]. At 0-0.1 μM for 24 hours, it significantly increases the oxygen consumption rate (OCR) in RKO cells with minimal changes in extracellular acidification rate (ECAR), upregulating p-AMPK and mitochondrial complexes III and V, indicating selective activation of OXPHOS in CRC [1]. |
| In vivo | AMPK activator 11 (Compound 18a) was administered intraperitoneally at doses of 2.5 or 10 mg/kg for 25 days, selectively inhibiting tumor growth in an RKO cell xenograft model in vitro without toxicity [1]. |
| Molecular Weight | 408.45 |
| Formula | C25H20N4O2 |
| Cas No. | 2948304-00-3 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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