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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-activated protein kinase (AMPK) and enhancement of oxidative phosphorylation (OXPHOS) (mitochondrial metabolism). This compound demonstrates particular efficacy in inhibiting RKO xenograft growth, rendering it useful for anti-tumor and metabolic disease research [1]. |
In vitro | AMPK activator 11 (Compound 18a) at 0-30 μM for 0-7 days inhibits growth and migration of CRC cells with an IC50 value below 1 μM [1]. When administered at 0-0.1 μM for 24 hours, it significantly increases the oxygen consumption rate (OCR) in RKO cells, while causing minimal changes in the extracellular acidification rate (ECAR). Additionally, AMPK activator 11 upregulates the expression of p-AMPK and mitochondrial complexes III and V, indicating a selective activation capability of OXPHOS in CRC [1]. |
In vivo | AMPK activator 11 (Compound 18a) at doses of 2.5 or 10 mg/kg was administered intraperitoneally for 25 days and selectively inhibited tumor growth in an RKO cell xenograft model in vitro without toxicity [1]. |
Molecular Weight | 408.45 |
Formula | C25H20N4O2 |
Cas No. | 2948304-00-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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