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Vinorelbine

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Catalog No. T0190Cas No. 71486-22-1
Alias KW-2307 base

Vinorelbine (KW-2307 base) is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase.

Vinorelbine

Vinorelbine

🥰Excellent
Purity: 99.64%
Catalog No. T0190Alias KW-2307 baseCas No. 71486-22-1
Vinorelbine (KW-2307 base) is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase.
Pack SizePriceAvailabilityQuantity
20 mg$90In Stock
1 mL x 10 mM (in DMSO)$70In Stock
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Purity:99.64%
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Product Introduction

Bioactivity
Description
Vinorelbine (KW-2307 base) is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase.
Targets&IC50
Proliferation (Hela cells):1.25 nM
In vitro
Vinorelbine (0.5-5 nM) inhibits cell proliferation by 50% (IC50) at 1.25 nM, with no cells in anaphase at 8 nM[1]. It time-dependently induces p53 and p21WAF1/CIP1 expression in androgen-dependent (AD) and -independent (AI) prostate cancer cell lines and stimulates reporter genes in a concentration-dependent manner[2].
In vivo
After vinorelbine treatment, the initial neutropenic episode occurred after the first administration in four dogs, the second in one dog, and the sixth in another dog [3]. In tumor-bearing cats, vinorelbine is tolerated at a weekly interval with a maximum tolerated dose (MTD) of 11.5 mg/m2 [4].
Kinase Assay
Reverse transcriptase assays: Reverse transcriptase assays are carried out in a reaction mixture (50 μL) containing 50 mM Tris-HCl (pH 7.5), 5 mM DTT, 100 mM potassium chloride, 0.01% Triton X-100 or NP40, 10 μg/ml (dT)15.(A)n as template primer and [3H] deoxythymidine triphospahate. The reaction mixture is incubated for 1 hr at 37 ℃ and stopped by the addition of 50 μg of yeast tRNA and 2 mL of 10% solution of trichloroacetic acid containing 1 mM sodium pyrophosphate. The samples are filtered on filters (0.45 μm), washed first with 5% TCA solution for 5 times and then with 2 ml of 70% ethanol. The filters are dried, scintillation fluid is added and the radioactivity counted in a counter.
AliasKW-2307 base
Chemical Properties
Molecular Weight778.93
FormulaC45H54N4O8
Cas No.71486-22-1
SmilesC(C)[C@@]12[C@]3([C@@]4([C@]([C@](C(OC)=O)(O)[C@@H]1OC(C)=O)(N(C)C=5C4=CC(=C(OC)C5)[C@]6(C(OC)=O)C7=C(C=8C(N7)=CC=CC8)C[N@@]9C[C@](C6)(C=C(CC)C9)[H])[H])CCN3CC=C2)[H]
Relative Density.1.36 g/cm3
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 10 mg/mL (12.84 mM)
DMSO: 100 mg/mL (128.38 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.2838 mL6.4191 mL12.8381 mL64.1906 mL
5 mM0.2568 mL1.2838 mL2.5676 mL12.8381 mL
10 mM0.1284 mL0.6419 mL1.2838 mL6.4191 mL
DMSO
1mg5mg10mg50mg
20 mM0.0642 mL0.3210 mL0.6419 mL3.2095 mL
50 mM0.0257 mL0.1284 mL0.2568 mL1.2838 mL
100 mM0.0128 mL0.0642 mL0.1284 mL0.6419 mL

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