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Mebendazole
Mebendazole (Mebenvet) is a hedgehog inhibitor, used as an antihelminthic.
Catalog No. T1155Cas No. 31431-39-7
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Purity:99.88%
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Mebendazole
Catalog No. T1155Cas No. 31431-39-7
Mebendazole (Mebenvet) is a hedgehog inhibitor, used as an antihelminthic.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 200 mg | $31 | In Stock | |
| 500 mg | $46 | In Stock | |
| 1 g | $53 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Mebendazole (Mebenvet) is a hedgehog inhibitor, used as an antihelminthic. |
| In vitro | mebendazole (MZ), a derivative of benzimidazole, induces a dose- and time-dependent apoptotic response in human lung cancer cell lines. MZ arrests cells at the G2-M phase before the onset of apoptosis. MZ treatment also results in mitochondrial cytochrome c release, followed by apoptotic cell death. Additionally, MZ appears to be a potent inhibitor of tumor cell growth with little toxicity to normal WI38 and human umbilical vein endothelial cells[2]. |
| In vivo | When administered p.o. to nu/nu mice, MZ strongly inhibits the growth of human tumor xenografts and significantly reduces the number and size of tumors in an experimental model of lung metastasis. MZ treatment significantly reduces vessel densities in mice compared with those in control mice[2]. |
| Cell Research | When grown to 40–50% confluence, the cells are exposed to MZ dissolved in DMSO. Cell growth is monitored by counting the viable cells using a hemacytometer.(Only for Reference) |
| Alias | Telmin, Mebenvet, Vermox, Pantelmin |
| Molecular Weight | 295.29 |
| Formula | C16H13N3O3 |
| Cas No. | 31431-39-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 10 mg/mL (33.87 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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