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Griseofulvin

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Purity:95.83%

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COA LCMS HNMR

Griseofulvin

Catalog No. T1382Cas No. 126-07-8

Griseofulvin (Fulvicin) is an antifungal agent used in the treatment of TINEA infections.

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Pack Size	Price	Availability	Quantity
500 mg	$41	In Stock

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Product Introduction

Bioactivity

Description	Griseofulvin (Fulvicin) is an antifungal agent used in the treatment of TINEA infections.
In vitro	Griseofulvin exhibits effective anti-infective activity in vivo. When administered in conjunction with nocodazole (5 mg/kg), Griseofulvin significantly enhances the efficacy of nocodazole, resulting in the cessation of tumor growth.
In vivo	In vitro tests have demonstrated that the minimum inhibitory concentration (MIC) of Griseofulvin against various dermatophytes ranges between 0.14 to 0.6 µg/mL. Griseofulvin's primary mechanism of action on cellular mitosis is the disassembly of spindle microtubules. Additionally, Griseofulvin has the capacity to induce chromosomal structural abnormalities in mammalian cells. It is effective in combating different types of skin fungi, including species from the genera Microsporum, Trichophyton, and Epidermophyton. However, it is not sensitive to other fungi, such as Scopulariopsis and Hendersonula, and has almost no effect on yeasts.
Cell Research	The cells (5× 103/mL) are incubated in triplicate in a 96-well plate in the presence or absence of indicated concentration of Griseofulvin in a final volume of 0.2 mL for different time intervals at 37 ℃. Thereafter, 20 μL MTT solution (5 mg/mL in PBS) is added to each well. After a 2-hour incubation at 37 ℃, 0.1 mL lysis buffer (20% SDS, 50% dimethylformamide) is added, incubation is continued overnight at 37 ℃, and then the optical density at 570 nm is measured by plate reader. (Only for Reference)
Alias	Fulvicin, Amudane, Grisactin

Chemical Properties

Molecular Weight	352.77
Formula	C17H17ClO6
Cas No.	126-07-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (170.08 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8347 mL	14.1735 mL	28.3471 mL	141.7354 mL
5 mM	0.5669 mL	2.8347 mL	5.6694 mL	28.3471 mL
10 mM	0.2835 mL	1.4174 mL	2.8347 mL	14.1735 mL
20 mM	0.1417 mL	0.7087 mL	1.4174 mL	7.0868 mL
50 mM	0.0567 mL	0.2835 mL	0.5669 mL	2.8347 mL
100 mM	0.0283 mL	0.1417 mL	0.2835 mL	1.4174 mL

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