SNIPER(TACC3)-11 is a potent degrader of the FGFR3-TACC3 protein, significantly reducing its levels and inhibiting the proliferation of FGFR3-TACC3-positive cancer cells [1].

SNIPER(TACC3)-11 (compound 5a), at concentrations of 0.3 to 3 µM over six hours, reduces FGFR3-TACC3 levels [1]. Additionally, a 72-hour exposure to the same concentration specifically inhibits RT4 cell proliferation at 3 µM without affecting HeLa cell growth [1].