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MI-2-2

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COA HPLC

MI-2-2

Catalog No. T28036Cas No. 1454920-20-7

MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.

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1 mg	$58	In Stock
5 mg	Inquiry	In Stock

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Product Introduction

Bioactivity

Description	MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.
In vitro	MI-2-2 is capable of inhibiting the bivalent fragment of MLL that comprises both MBM1 and MBM2 with IC50 of 520 nM. MI-2-2 potently inhibits cell proliferation, differentiation and down-regulation of Hoxa9 expression. MI-2-2 exhibits pronounced activities at low micromolar concentrations in BMCs transformed with MLL-AF9 and in MV4[1].
Alias	MI22, MI 2 2

Chemical Properties

Molecular Weight	415.5
Formula	C17H20F3N5S2
Cas No.	1454920-20-7

Storage & Solubility Information

Storage	keep away from direct sunlight,store at low temperature Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility Information	DMSO: Soluble

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