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Ciglitazone

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Purity:98.23%

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COA HPLC HNMR

Ciglitazone

Catalog No. T19710Cas No. 74772-77-3

Ciglitazone (ADD 3878) is a potent and selective PPARγ agonist (EC50: 3 μM) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation of th17 cells, decreases insulin levels, vascular endothelial growth factor production and blood pressure, and induces cell cycle arrest in gastric cancer cells. Selegiline induces apoptosis in opossum kidney epithelial cells and activates nuclear translocation of p38 MAPK and apoptosis-inducing factor (AIF). Ciglitazone exhibits hypoglycaemic activity in animal models of obesity and hyperglycaemia.

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Pack Size	Price	Availability	Quantity
5 mg	$91	In Stock

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Product Introduction

Bioactivity

Description	Ciglitazone (ADD 3878) is a potent and selective PPARγ agonist (EC50: 3 μM) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation of th17 cells, decreases insulin levels, vascular endothelial growth factor production and blood pressure, and induces cell cycle arrest in gastric cancer cells. Selegiline induces apoptosis in opossum kidney epithelial cells and activates nuclear translocation of p38 MAPK and apoptosis-inducing factor (AIF). Ciglitazone exhibits hypoglycaemic activity in animal models of obesity and hyperglycaemia.
In vitro	Ciglitazone (0-20 μM ; 24 hours) ciglitazone causes the generation of ROS and an increase in intracellular Ca2+ and induces apoptosis through a PPAR-independent mechanism.[4]
In vivo	Ciglitazone (100 mg/kg/day ; 2 days ; C57BL/6J-ob/ob mice) elicits a drastic fall in blood glucose.[3] Ciglitazone (100 mg/kg/day ; 41-44 days ; ob/ob mice) degranulation of islet beta-cells and increased pancreatic insulin content are observed.[3]
Alias	Ciglitazona, U 63287, ADD3878, ADD-3878, U-63287, ADD 3878

Chemical Properties

Molecular Weight	333.45
Formula	C18H23NO3S
Cas No.	74772-77-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (269.9 mM )

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9990 mL	14.9948 mL	29.9895 mL	149.9475 mL
5 mM	0.5998 mL	2.9990 mL	5.9979 mL	29.9895 mL
10 mM	0.2999 mL	1.4995 mL	2.9990 mL	14.9948 mL
20 mM	0.1499 mL	0.7497 mL	1.4995 mL	7.4974 mL
50 mM	0.0600 mL	0.2999 mL	0.5998 mL	2.9990 mL
100 mM	0.0300 mL	0.1499 mL	0.2999 mL	1.4995 mL

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