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C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $34 | In Stock | |
5 mg | $55 | In Stock | |
10 mg | $93 | In Stock | |
25 mg | $189 | In Stock | |
50 mg | $297 | In Stock | |
100 mg | $493 | In Stock | |
1 mL x 10 mM (in DMSO) | $61 | In Stock |
Description | C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation. |
In vitro | The addition of C-4 (mTOR inhibitor-1, 0~12.8 μg/ml) directly decreases the level of activated mTOR (p-mTORser2448) which is phosphorylated at Ser2448. The proliferation of A549 cells is strongly inhibited by C-4, and the inhibitory effect is time- and dose314 dependent. The IC50 of C-4 at 24 h is calculated as 3.176 μM. |
Molecular Weight | 363.21 |
Formula | C16H15BrN2O3 |
Cas No. | 468747-17-3 |
Smiles | C\C(=N/NC(=O)c1ccc(C)c(Br)c1)c1ccc(O)cc1O |
Relative Density. | 1.48 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 70 mg/mL (192.72 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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