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PQR514 is a potent PI3K inhibitor with anticancer activity and inhibits cancer cell proliferation.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $333 | In Stock | |
5 mg | $790 | In Stock | |
10 mg | $1,120 | In Stock | |
25 mg | $1,670 | In Stock | |
50 mg | $2,180 | In Stock |
Description | PQR514 is a potent PI3K inhibitor with anticancer activity and inhibits cancer cell proliferation. |
In vivo | METHODS: A single oral dose of PQR514 (10 mg/kg) was administered to male C57BL/6J mice at plasma concentrations of 4 and brain and thigh muscle concentrations were monitored over time. RESULTS: PQR514(4) reached maximum concentrations in plasma (3282ng/mL) after 1 hour and in brain and thigh muscles after 30 minutes (1023 and 1808 ng/g, respectively). METHODS: Using the OVCAR-3 xenograft model in BALB/c nude mice, the treatment group received PQR514 (6.3 mg/kg, p.o. QD 28 days) starting on day 17 to evaluate the in vivo anti-proliferative effect of PQR514. RESULTS: PQR514 treatment resulted in significant anti-tumor activity, with PQR514 significantly inhibiting tumor growth compared to control mice. [1] |
Molecular Weight | 394.38 |
Formula | C16H20F2N8O2 |
Cas No. | 1927857-55-3 |
Smiles | FC(F)C1=NC(=NC=C1C2=NC(=NC(=N2)N3CCOCC3)N4CCOCC4)N |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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