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KEA1-97

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Purity:98.7%

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COA HNMR LCMS

KEA1-97

Catalog No. T9118Cas No. 2138882-71-8

Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and caspase 3 and activates caspases without affecting the activity of thioredoxin.

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Pack Size	Price	Availability
2 mg	$34	In Stock
5 mg	$55	In Stock
10 mg	$89	In Stock
25 mg	$169	In Stock
50 mg	$313	In Stock
100 mg	$493	In Stock
200 mg	$698	In Stock
1 mL x 10 mM (in DMSO)	$61	In Stock

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Product Introduction

Bioactivity

Description	Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and caspase 3 and activates caspases without affecting the activity of thioredoxin.
In vitro	KEA1-97 (10 μM, 48h) impaired 231MFP cell survival and proliferation and does not affect viability in MCF10A cells.
In vivo	KEA1–97 treatment (5 mg/kg ip once per day) was initiated 16 days after the initiation of 231MFP tumor xenografts in immune-deficient SCID mice.

Chemical Properties

Molecular Weight	335.16
Formula	C15H9Cl2FN4
Cas No.	2138882-71-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL(268.53 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9836 mL	14.9182 mL	29.8365 mL	149.1825 mL
5 mM	0.5967 mL	2.9836 mL	5.9673 mL	29.8365 mL
10 mM	0.2984 mL	1.4918 mL	2.9836 mL	14.9182 mL
20 mM	0.1492 mL	0.7459 mL	1.4918 mL	7.4591 mL
50 mM	0.0597 mL	0.2984 mL	0.5967 mL	2.9836 mL
100 mM	0.0298 mL	0.1492 mL	0.2984 mL	1.4918 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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