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TC-S 7003
🥰Excellent
Catalog No. T15726Cas No. 847950-09-8
Alias Lck Inhibitor
TC-S 7003 (Lck Inhibitor) is an orally active, selective and potent lymphocyte kinase (Lck) inhibitor with anti-inflammatory activity, inhibition of Lck, Lyn, Src, and Syk kinases, and inhibition of T-cell proliferation, and may be useful in the study of arthritis.
TC-S 7003
🥰Excellent
Purity: 99.74%
Catalog No. T15726Alias Lck InhibitorCas No. 847950-09-8
TC-S 7003 (Lck Inhibitor) is an orally active, selective and potent lymphocyte kinase (Lck) inhibitor with anti-inflammatory activity, inhibition of Lck, Lyn, Src, and Syk kinases, and inhibition of T-cell proliferation, and may be useful in the study of arthritis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 5 mg | $116 | In Stock | |
| 10 mg | $186 | In Stock | |
| 25 mg | $422 | In Stock | |
| 50 mg | $749 | In Stock | |
| 100 mg | $1,420 | In Stock | |
| 500 mg | $2,830 | In Stock |
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Purity:99.74%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | TC-S 7003 (Lck Inhibitor) is an orally active, selective and potent lymphocyte kinase (Lck) inhibitor with anti-inflammatory activity, inhibition of Lck, Lyn, Src, and Syk kinases, and inhibition of T-cell proliferation, and may be useful in the study of arthritis. |
| Targets&IC50 | IL-2:0.46 μM, T cells:0.53 μM |
| In vitro | TC-S 7003 exhibited good potency in the T-cell receptor-induced IL-2 secretion assay (IL- 2) and also inhibited subsequent T-cell proliferation (T-cell prolif.) in the same human T -cells, IL-2, IC50=0.46 μM, T-cell prolif, IC50=0.53 μM. [1] |
| In vivo | A once-daily dose of TC-S 7003 was administered orally at 10, 30, and 60 mg/kg from day 9 to day 17. TC-S 7003 showed a dose-dependent inhibition of arthritis (ED50=24 mg/kg). [1] |
| Alias | Lck Inhibitor |
| Molecular Weight | 530.62 |
| Formula | C31H30N8O |
| Cas No. | 847950-09-8 |
| Smiles | O=C1C2=CN=C(N=C2N3C(=NC=4C=CC=CC43)N1C=5C(=CC=CC5C)C)NC6=CC=C(C=C6)N7CCN(C)CC7 |
| Relative Density. | 1.36 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL(150.77 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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